Changes in brain response after transcranial electrical stimulation in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study combines transcranial direct current stimulation (tDCS) or transcranial alternating current stimulation (tACS) with conventional physical therapy and cognitive-motor dual-task gait training. Participants include adults aged 18-80 with unilateral stroke occurring 2 weeks to 5 years prior, able to walk with or without aids, and with adequate cognitive function. Hemodynamic changes in the brain will be measured using functional near-infrared spectroscopy (fNIRS) to assess oxy- and deoxyhemoglobin during rehabilitation tasks. The study aims to understand how tES modalities influence cerebral blood flow and oxygen consumption when paired with rehabilitation in subacute to chronic stroke survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Unilateral stroke individuals aged 18-80 years.
2. A first-ever stroke.
3. Stroke onset from at least 2 weeks-5 years.
4. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
5. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
6. Ability to read, communicate, follow and understand instructions.

Exclusion Criteria:

1. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
2. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
3. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
4. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.
5. Presence of an opened wound, infectious wound around scalp or craniectomy with unreplaced bone flap
6. Moderate pain (numeric pain rating score \> 4/10) in any joint of the upper or lower limb, whether paretic or non-paretic
7. Presence of color blindness
8. Presence of any substance use including cannabis and kratom

Where it's running

• Faculty of Physical Therapy, Mahidol University
  Salaya, Changwat Nakhon Pathom, Thailand Recruiting

Study contacts

• Study coordinator: Wanalee Klomjai, PhD
• Email: wanalee.klo@mahidol.edu
• Phone: +6624415450

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Noninvasive brain stimulation plus cognitive-motor dual-task gait training to improve thinking and walking after stroke

  This trial will test whether adding high-definition noninvasive brain stimulation (tDCS or tACS) to cognitive-motor dual-task gait training and standard physical therapy helps thinking, brain activity, spinal reflexes, and walking in adults 2 weeks to 5 years after a stroke.

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• Remotely Delivered Step Count Rehab After Stroke

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• Best Care for Acute Stroke in General Wards

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• Vibration plus electrical stimulation to improve ankle lifting after subacute ischemic stroke

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• Using Atorvastatin to Prevent Stroke After Flow Diverter Implantation

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• Machine learning and blood tests to detect delayed cerebral ischemia early

  This project will test whether combining machine learning with brain-related blood markers and bedside monitoring can spot or predict delayed cerebral ischemia in adults with aneurysmal subarachnoid hemorrhage in intensive care.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.