Noninvasive brain stimulation plus cognitive-motor dual-task gait training to improve thinking and walking after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with a first-ever unilateral stroke (2 weeks to 5 years post-onset) receive either active high-definition transcranial direct current stimulation (tDCS), active high-definition transcranial alternating current stimulation (tACS), or sham stimulation combined with conventional physical therapy and cognitive-motor dual-task gait training. The study measures cortical activity with EEG and event-related potentials, spinal motoneuron excitability via H-reflex, cognitive performance, and gait/motor outcomes before and after the intervention. Changes in physiological markers and functional performance are compared across intervention arms to determine whether adding tES yields greater improvements than training alone. All sessions are delivered in person at the Faculty of Physical Therapy, Mahidol University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Unilateral stroke individuals aged 18-80 years.
2. A first-ever stroke.
3. Stroke onset from at least 2 weeks-5 years.
4. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
5. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
6. Ability to read, communicate, follow and understand instructions.

Exclusion Criteria:

1. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
2. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
3. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
4. Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.
5. Presence of an opened wound, infectious wound around scalp or craniectomy with unreplaced bone flap
6. Moderate pain (numeric pain rating score \> 4/10) in any joint of the upper or lower limb, whether paretic or non-paretic
7. Presence of color blindness
8. Presence of any substance use including cannabis and kratom

Where it's running

• Faculty of Physical Therapy, Mahidol University
  Nakhon Pathom, Thailand Recruiting

Study contacts

• Study coordinator: Wanalee Klomjai, PhD
• Email: wanalee.klo@mahidol.edu
• Phone: +6624415450

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.