Machine learning and blood tests to detect delayed cerebral ischemia early

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study of adults with aneurysmal subarachnoid hemorrhage admitted to the ICU at Sahlgrenska University Hospital. Researchers will collect serial blood and cerebrospinal fluid samples for neurospecific biomarkers (GFAP, NSE, total tau, S-100, neurofilament light chain) and continuously record physiologic signals including heart rate variability, EEG, near-infrared spectroscopy, and measures of cerebral autoregulation. Machine learning models will integrate these biomarkers and monitoring features to detect or predict episodes of delayed cerebral ischemia, and biomarker levels will be compared with long-term functional outcomes using the Glasgow Outcome Scale Extended at 1, 3, and 5 years. No interventional treatments are given as part of the protocol; data are intended to develop an early warning approach that could be deployed at the bedside if validated.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients over the age of 18 with aneurysmal subarachnoid hemorrhage admitted to intensive care units at Sahlgrenska University hospital.

Exclusion Criteria:

* Unable to consent,
* Cardiac arrythmia,
* Previous brain damage

Where it's running

• Sahlgrenska University Hospital
  Gothenburg, Sweden Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.