BK virus in kidney transplant patients and donors: who carries the virus and why

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes BK polyomavirus replication in urine of kidney transplant recipients and the potential donor origin of the virus. It aims to link viral genotype with the recipient’s immune response and see how urine viral profiles relate to immune activity. Participants are adults with a first BK viruria after transplant, more than 3 months but less than 2 years post-transplant, from Grenoble Alpes University Hospital. The study will explore biomarkers and genotypic matches to distinguish donor-derived from recipient-derived BKV and how immune responses vary with viruria. No interventional treatment is described; the focus is on characterizing viral origin and host response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Kidney transplant patients with a first positive BK virus viral load in urine. - BK virus viral load in urine \> 3 log copies/mL.
* More than 3 months post-transplant and less than 2 years post-transplant.
* Men or women aged 18 years and older.
* Followed up at Grenoble Alpes University Hospital.
* Affiliated with social security or beneficiary of such a scheme.
* Patients who are not opposed to the TYPIK study.

Exclusion Criteria:

* Expected renal graft survival is \< 6 months, estimated by an eGFR \< 15 mL/min/1.73 m² at the time of BKPyV viruria
* Patients who object to the use of their data and/or samples for research purposes
* Subjects who are excluded from another study
* Subjects under administrative or judicial supervision

Where it's running

• Chuga
  Grenoble, France Recruiting

Study contacts

• Principal investigator: Aurélie TRUFFOT — Chuga
• Study coordinator: Aurélie TRUFFOT, PHD
• Email: atruffot@chu-grenoble.fr
• Phone: 0786498337

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.