Fructose and Aging: How sugar affects the gut barrier in healthy adults
Official title: Investigation of the Effect of Fructose on Health Parameters and the Intestinal Barrier in Healthy Individuals
Run by University of Vienna · NCT07757347 · Data updated 2026-11-12
This study tests whether fructose affects the intestinal barrier and health markers in healthy people aged 18 and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | July 2027 |
| Study ends | December 2027 |
| Registry record updated | August 11, 2026 |
| Trial ID | NCT07757347 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older who are healthy and do not have the listed medical exclusions or special dietary restrictions.
✕Probably not a fit
Individuals with metabolic, gastrointestinal, liver, kidney conditions, or other listed exclusions may not experience any benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of fructose consumption on health parameters and the intestinal barrier in a healthy adult population. Participants will be given fructose and glucose, with measurements taken to assess gut permeability and related immune responses. The trial applies an interventional design to observe physiological changes linked to fructose intake. Exclusion criteria exclude individuals with certain metabolic, gastrointestinal, or systemic conditions to minimize confounding factors. The study is led by the University of Vienna and conducted at their Vienna campus.
Why it matters
Potential benefit: If successful, the study could clarify how fructose affects gut health and its possible implications for overall health in healthy adults.
How similar studies have gone: Previous research on sugar intake and gut permeability has yielded mixed results, making this study a meaningful contribution to understanding fructose's effects in healthy individuals.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all gender, healthy collective ≥ 18 years old Exclusion Criteria: * Chronic inflammatory diseases of the gastrointestinal tract * Metabolic diseases or taking medication to treat metabolic diseases * Fructose malabsorption * Hereditary fructose intolerance * Food intolerances and/or allergies, as well as food allergies that require special dietary interventions * Special diets, such as vegetarian/vegan diets * Unstable body weight within the last 6 months (fluctuations of \> 5%) * BMI \< 19 kg/m2 \& \> 29,9 kg/m2 * Bariatric surgery * Smoking * Liver diseases * Renal insufficiency * Rheumatoid arthritis * COPD with ≥ 2 exacerbations per year * Chronic pancreatitis or recurrent acute pancreatitis * Alcohol consumption above 10 g/d for women and above 20 g/d for men * Pregnancy and breastfeeding * Viral or bacterial infections that occurred no longer than 3 weeks ago
Where it's running
-
University of Vienna
Vienna, Austria Recruiting
Study contacts
- Study coordinator: Ina Bergheim, Prof.
- Email: ina.bergheim@univie.ac.at
- Phone: +43-1-4277-54981
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.