Pre-treatment exercise to improve outcomes for people with oesophageal adenocarcinoma
Official title: Optimising Prehabilitation Exercise to Enhance Tumour Outcomes in Advanced Oesophageal Cancer
Run by University of Surrey · NCT07375420 · Data updated 2026-11-12
This trial will test whether a short programme of low- or high-intensity exercise before chemotherapy and surgery helps people with resectable oesophageal adenocarcinoma by increasing immune activity in tumours and improving recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Surrey Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (Guildford, Surrey) |
| Status | Recruiting |
| Started | April 26, 2024 |
| Main results expected | April 30, 2027 |
| Study ends | October 30, 2028 |
| Registry record updated | February 2, 2026 |
| Trial ID | NCT07375420 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with resectable oesophageal adenocarcinoma who are planned for neoadjuvant chemotherapy followed by surgery and who can safely perform cardiopulmonary exercise testing and the exercise programmes.
✕Probably not a fit
People who cannot safely exercise because of other health conditions, those with unresectable or metastatic disease, pregnant people, and anyone under 18 are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study enrolls adults with resectable oesophageal adenocarcinoma who are planned for neoadjuvant chemotherapy followed by surgery and asks them to undertake either a low-intensity or high-intensity exercise programme before treatment. Researchers will collect tumour tissue, blood, fitness measures and stool samples to measure immune cells in the tumour, systemic immune responses, fitness changes and shifts in the gut microbiome. The goal is to see whether exercise increases immune cell infiltration into tumours and produces measurable biological changes that could make standard treatments work better. The protocol builds on animal studies showing exercise-driven tumour immune changes and limited human data on exercise effects during cancer care.
Why it matters
Potential benefit: If successful, pre-treatment exercise could increase immune activity in tumours, improve treatment response and recovery, and potentially shorten hospital stays.
How similar studies have gone: Animal studies show exercise can boost tumour immune cells, human data are limited and prior short-term human work has not yet demonstrated clear tumour immune effects.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults with resectable oesophageal adenocarcinoma who are planned for neoadjuvant chemotherapy followed by surgery Exclusion Criteria: * Inability to carry out CPET or exercise due to underlying health conditions * pregnancy * \<18 years old
Where it's running
-
University of Surrey
Guildford, Surrey, United Kingdom Recruiting
Study contacts
- Principal investigator: Adam Frampton, PhD — University of Surrey
- Study coordinator: Jamal Dirie, MD
- Email: jd01928@surrey.ac.uk
- Phone: +447944688517
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.