BSAFE: Brief Intervention to Reduce Fentanyl Risk for stimulant users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares the BSAFE intervention, which includes an overdose education curriculum based on the IMB model, to an attention-control condition. Participants are adults who use stimulants, test positive for cocaine or methamphetamine and do not have opioids/fentanyl in their system at enrollment. The study evaluates whether the BSAFE program reduces overdose risk behaviors and improves safety practices over time. Recruitment is limited to sites affiliated with the San Francisco Department of Public Health and UCSF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18 years or older,
2. Reports intentional cocaine or methamphetamine use ≥7 of past 30 days,
3. Urine positive for cocaine or methamphetamine and negative for opioids/fentanyl prior to enrollment
4. Be able to provide the names of at least 2 persons who can consistently locate their whereabouts.
5. Reports at least one suspected unintentional fentanyl use event, including unexpected sedation or unexpected fentanyl-positive bodily fluid drug testing result.

Exclusion Criteria:

1. Reports past 30-day intentional use of any opioid or ongoing use of an opioid antagonist (e.g., naltrexone)
2. Intends to leave area in coming year,
3. Unable to communicate in English or Spanish,
4. Any other condition that, in the PI's judgment, interferes with safe study participation or adherence to study procedures.

Where it's running

• San Francisco Department of Public Health
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Alexander Bazazi, MD, PhD — University of California, San Francisco
• Study coordinator: Phillip O Coffin, MD, MIA
• Email: phillip.coffin@sfdph.org
• Phone: (628) 217-6282

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• The ENHANCE Project Toolkit

  This pilot study tests a bundle of smartphone and online tools to help people who use drugs reduce overdose risk.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07649278

• Recognizing dapagliflozin overdose in ICU patients admitted for metformin poisoning.

  This project will see if clinical signs and routine lab tests can help doctors tell whether adults in the ICU for metformin poisoning also took too much dapagliflozin.

  Recruiting Centre Hospitalier de Saint-Denis · Saint-Denis, France · NCT07193069

• Social intervention for overdose prevention and education

  This study is trying out a program that teaches people who use opioids and their friends and family how to prevent and respond to drug overdoses.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland · NCT06327061

• Peer-driven intervention to prevent HIV, HCV, and drug overdoses among people who inject drugs

  This study is testing whether getting support and education from peers can help people who inject drugs reduce their risk of HIV, hepatitis C, and overdoses.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland · NCT05320835

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.