Biobank for studying gut microbiota and its effects on inflammatory bowel diseases and colorectal cancer
Digestive Biobank for Exploring Microbiota-host Interactions
Assistance Publique - Hôpitaux de Paris · NCT05704413
This study is collecting samples from people with inflammatory bowel diseases and colorectal cancer to see how gut bacteria affect their health and treatment outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Paris) |
| Trial ID | NCT05704413 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a biobank consisting of tissue, blood, plasma, and stool samples from patients with inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, as well as colorectal cancer. The goal is to identify biomarkers associated with treatment responses and postoperative complications, including neuro-cognitive and mood issues. By exploring the interactions between gut microbiota and the immune system, the study seeks to enhance understanding of these chronic conditions and their physiopathology. All samples collected will be anonymized to protect patient privacy.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with ulcerative colitis, Crohn's disease, or colorectal cancer who are undergoing digestive resection.
Not a fit: Patients under 18 years old will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and better management of inflammatory bowel diseases and colorectal cancer.
How similar studies have performed: Other studies have shown promise in exploring microbiota interactions in similar conditions, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ulcerative colitis, Crohn's disease or colorectal disease * Digestive resection with useless tissue available * Information consent signed Exclusion Criteria: \- Patients \< 18 years
Where this trial is running
Paris
- Service de Chirurgie Viscérale - Hôpital Saint Antoine — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Jérémie LEFEVRE, PU-PH — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Jérémie LEFEVRE, PU-PH
- Email: jeremie.lefevre@aphp.fr
- Phone: +33 (0)1 49 28 25 63
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Colorectal Cancer, Indeterminate Colitis, Microbiota, inflammatory bowel disease, Crohn's disease