Analyzing dental enamel defects using color measurement techniques

Colorimetric Comparison of Email Defects Using Spectrophotometric and Computer Techniques and Biological, Structural and Physico-chemical Analyses of Teeth or Pathological Enamel

This study is testing a new way to check for enamel problems in teeth, like discoloration and defects, to help people with conditions like Amelogenesis Imperfecta and dental fluorosis.

Quick facts

• Study type: Observational
• Enrollment: 80 (estimated)
• Ages: 8 Years to 55 Years
• Sex: All
• Sponsor: Assistance Publique - Hôpitaux de Paris (Academic / other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Paris)
• Trial ID: NCT04704089 on ClinicalTrials.gov

What this trial studies

This observational study focuses on the analysis of enamel defects, specifically targeting conditions such as Amelogenesis Imperfecta, dental fluorosis, and Molar Incisor Hypomineralization. It employs a spectrophotometer to measure tooth colors as a non-invasive diagnostic tool for early detection of enamel abnormalities. Participants will undergo screening and follow-up visits where dental samples will be collected for biological, structural, and physicochemical analyses. The study aims to enhance understanding of these enamel pathologies and improve diagnostic methods.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 8 to 55 who have one of the specified enamel anomalies.

Not a fit: Patients with pre-eruptive anomalies limited to molars or those with other types of hypomineralization may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved early diagnosis and management of enamel defects, benefiting patients with these conditions.

How similar studies have performed: While similar studies have explored enamel defects, the specific use of a spectrophotometer for early diagnosis in this context is relatively novel.

Eligibility criteria

For patients :

Inclusion Criteria :

1. Age between 8 and 55 years old
2. Carrier of one of the following 3 quantitative pre-eruptive enamel anomalies : AIH, dental fluorosis or MIH
3. Information and collection of the non-opposition of the adult patient or of the representative(s) of parental authority present for the minors.

Criteria for non-inclusion :

1. Pregnant or breastfeeding woman
2. Under guardianship or curators
3. Opposition of the minor patient
4. Presenting pre-eruptive anomalies only on the molars (the spectrophotometer can only take pictures of the anterior dental sector (incisors and canines)).
5. Other types of hypomineralization (post-eruptive, of traumatic or infectious origin, idiopathic).
6. Having undergone radiotherapy or chemotherapy inducing dental and periodontal damage.
7. Having systemic abnormalities (unbalanced diseases), haemochromatosis, porphyria
8. Under medication likely to disturb the coloring of the teeth

For witnesses :

Inclusion Criteria :

1. Age between 8 and 55 years old
2. Information and collection of the non-opposition of the adult witness or of the representative(s) of parental authority present for the minors.
3. Free of any anomaly of tooth structure, exogenous dyschromia and carious lesions.

Criteria for non-inclusion :

1. Pregnant or breastfeeding woman
2. Under guardianship or curators
3. Opposition of the minor witness
4. Carrier of a quantitative pre-eruptive enamel anomaly
5. Polycarpus (preventing the diagnosis of amyl hypomineralization)

Where this trial is running

Paris

• Service d'odontologie, Hôpital Pitié-Salpêtrière — Paris, France (Recruiting)

Study contacts

• Study coordinator: Sophia HOUARI, MCU-PH

Conditions Amelogenesis Imperfecta; Dental Fluoroses; Hypomineralization Molar Incisor; Colorimetry; Dental Fluorosis; Molar-incisor-Hypomineralization; Developmental Enamel Defects; Shade selection