Alpha brain waves and time to wake after anesthesia in adults
Official title: An Observational Prospective Study of Anesthetic Sensitivity Assessed by Alpha Band Power and Its Association With Emergence Time From Sevoflurane General Anesthesia in Young Adults.
Run by University of Chile · NCT07254975 · Data updated 2026-11-12
This study tests whether lower alpha power during anesthesia is linked to longer awakening times in adults undergoing elective general anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 35 Years to 50 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | University of Chile Academic / other |
| Locations | 1 site (Santiago, RM) |
| Status | Recruiting |
| Started | October 30, 2025 |
| Main results expected | August 31, 2027 |
| Study ends | August 31, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07254975 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 35-50 with ASA I-II undergoing elective surgery and no neurological or psychiatric disorders.
✕Probably not a fit
Patients with significant comorbidities, neurological conditions, or those on psychotropic or opioid medications may not experience the expected benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study records intraoperative EEG to examine if alpha band power relates to emergence time after stopping sevoflurane anesthesia. Participants are adults aged 35-50 with ASA I-II undergoing elective surgery, monitored with a standard BIS EEG device. Emergence time is precisely measured after cessation of anesthetic gases, and results will indicate whether alpha activity can help predict recovery speed. The study uses a standardized GA protocol and analyzes the relationship between EEG patterns and awakening duration. No intervention beyond routine monitoring is planned.
Why it matters
Potential benefit: If successful, the findings could improve understanding of how brain activity relates to anesthesia recovery and potentially guide personalized anesthetic management.
How similar studies have gone: Prior research suggests alpha power may relate to anesthesia depth and recovery, but this specific association in this population is still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Elective surgery under general anesthesia * Age 35-50 years * ASA physical status I-II Exclusion Criteria * Neurological or psychiatric disorders * Use of psychotropic drugs or opioids * Altered consciousness * BMI \> 35 kg/m² * Renal, cardiac, or hepatic dysfunction * Emergency surgery * Pregnancy * Regional anesthesia
Where it's running
-
Hospital Clinico de la Universidad de Chile
Santiago, Rm, Chile Recruiting
Study contacts
- Study coordinator: Antonello Penna, MD, PhD
- Email: apenna@uchile.cl
- Phone: +56229788209
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Greater auricular nerve block to reduce agitation after children's middle ear surgery
This trial will test whether an ultrasound-guided greater auricular nerve block can reduce agitation and pain when children wake up after microscopic middle ear surgery.
-
AIRE: Self-care breathing and activity guidance to prevent complications from acute respiratory infections
This pilot test checks if adults aged 60–80 with an acute respiratory infection can use a breathing self-care program at home and stay engaged for 14 days to see if it prevents complications.
-
Expectancy Focused Exposure for Anxiety Disorders
We test whether Expectancy Focused Exposure helps reduce anxiety symptoms and prevent fear from coming back better than Anxiety Focused Exposure in adults with anxiety disorders.
-
Multimodal Telerehabilitation vs Face-to-Face Care for Adults with Hemophilia and Chronic Pain
This trial tests whether a 6-week telerehabilitation program combining pain education and therapeutic exercise works as well as in-person care for adults with hemophilia and chronic pain.
-
NeoMayor: a smartphone-guided lifestyle program to improve heart health in older adults in Chile
A smartphone app helps older adults at cardiovascular risk in Chile try better physical activity, diet, sleep, and well-being to see if their heart health improves.
-
Omega-3 fats to reduce inflammation in adults with newly diagnosed celiac disease
This study tests whether adding omega-3 fatty acid supplements to a gluten-free plan helps reduce inflammation and promote intestinal healing in adults who have just been diagnosed with celiac disease.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.