Multimodal Telerehabilitation vs Face-to-Face Care for Adults with Hemophilia and Chronic Pain
Official title: Effects of a Multimodal Telerehabilitation Intervention Versus Face-to-Face Care in Adults With Hemophilia and Chronic Pain: A Randomized Controlled Non-Inferiority Trial
Run by University of Chile · NCT07682519 · Data updated 2026-11-12
This trial tests whether a 6-week telerehabilitation program combining pain education and therapeutic exercise works as well as in-person care for adults with hemophilia and chronic pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | Men only |
| Enrollment | 24 (estimated) |
| Sponsor | University of Chile Academic / other |
| Locations | 1 site (Santiago, Santiago Metropolitan) |
| Status | Recruiting |
| Started | July 2, 2026 |
| Main results expected | January 15, 2027 |
| Study ends | January 15, 2027 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07682519 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Male adults aged 18–60 with hemophilia A or B, chronic pain for at least 3 months (or most days in 6 months), pain in elbow/knee/ankle, on prophylactic factor therapy, and able to consent and participate.
✕Probably not a fit
Individuals who do not experience similar outcomes with telerehabilitation or who have conditions limiting remote exercise participation may see no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, randomized, assessor-blinded, parallel-group non-inferiority trial comparing a 6-week multimodal telerehabilitation program to an equivalent face-to-face program in adults with hemophilia and chronic pain. Participants will be assigned 1:1 to either telerehabilitation or in-person care, with outcomes assessed before and after by an assessor unaware of group assignment. The intervention blends pain science education with therapeutic exercise, delivered either remotely or in person. Telerehabilitation aims to improve access by reducing travel needs while maintaining treatment adherence. The study is conducted at the University of Chile and focuses on adults with hemophilia A or B who have chronic pain in the elbow, knee, or ankle and are on prophylactic clotting factor therapy.
Why it matters
Potential benefit: If successful, patients could access effective rehabilitation remotely, potentially reducing travel burden without compromising outcomes.
How similar studies have gone: Previous pilots suggest telerehabilitation can match in-person care for musculoskeletal rehabilitation, but this specific approach in hemophilia has not been previously established in randomized trials.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Male adults aged 18 to 60 years. Diagnosis of hemophilia A or hemophilia B. Chronic pain, defined as pain occurring every day for at least 3 months or on at least half of the days during the previous 6 months. Pain involving the elbow, knee, or ankle. Receiving prophylactic clotting factor replacement therapy at least three times per week. Current medical referral for physical therapy. Residence in the Metropolitan Region of Chile. Ability to understand study procedures and provide written informed consent. Exclusion Criteria: Inability to understand study instructions or provide written informed consent. Neurological disorders affecting the central nervous system (e.g., stroke). Current participation in alternative therapies for pain management. Previous participation in a pain neuroscience education program. Orthopedic surgery or major musculoskeletal trauma within the previous 12 months.
Where it's running
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Department of Physical Therapy, Faculty of Medicine, University of Chile
Santiago, Santiago Metropolitan, Chile Recruiting
Study contacts
- Study coordinator: Rodrigo Núñez-Cortés, PhD
- Email: r_nunez@uchile.cl
- Phone: +56928777254
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.