Sponsor or institution
Clinical trials and research at Whitehead Institute for Biomedical Res
As of November 12, 2026, Find a Trial lists 34 NIH-funded research projects at this institution, with $24.5 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 34NIH research projects
NIH-funded research (34)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Illuminating the dark proteome to fight cancer
A research program aims to map and understand mysterious dark proteome proteins in cancer and to develop pre-clinical therapies that target them.
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Center for Genome Editing and Recording: Next-Generation Genome and Epigenome Tools for Disease
A research center is developing ultra-precise genome and epigenome editing tools to better understand and treat human diseases, with a focus on how genetic variants influence disease and how to safely modify them.
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Understanding how polyamines work in human cells (a potential cancer focus)
Researchers are studying how small molecules called polyamines help cancer-related cell growth and survival, with new ways to measure them inside living cells.
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Delivering therapeutic macromolecules with cell-derived bioparticles
A researcher aims to safely and efficiently deliver big therapeutic molecules into human cells using cell-derived bioparticles to help treat diseases.
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Stem cell and regeneration rules in planarians
Researchers study how planarians regulate stem cells to regrow body parts, hoping to reveal ideas that could someday help human tissue repair.
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Post-transcriptional gene regulation in human cells
A grant studying how microRNAs control which genes are turned on or off in human cells, with a focus on cancer and development.
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Understanding how cells separate chromosomes during division
Researchers are mapping the molecular machines in human cells that make sure chromosomes split correctly during division, which matters for conditions like cancer and some birth defects.
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Exploring animal hibernation for human health
This project looks at how animals can slow down their body functions, hoping to find new ways to help people with conditions like cancer, stroke, or heart problems.
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Understanding how chromatin and immune responses affect tumor growth in lung and pancreatic cancers
This study is looking at how certain changes in cancer cells and the immune system affect late-stage lung and pancreatic cancers, with the hope of finding new ways to treat these aggressive cancers and improve outcomes for patients.
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How polyamines work inside cells
This project builds new lab tools to track and understand cellular polyamines to help people with cancers and other polyamine-related disorders.
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Understanding how gene regulation affects pancreatic cancer
This study is looking at how changes in genes and their regulation affect pancreatic cancer, with the goal of finding new ways to treat this tough disease.
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Understanding how cells communicate during organ development
This study is looking at how two types of cells work together to help our organs grow and heal, and it aims to find new ways to use this knowledge to improve treatments for organ-related issues.
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Understanding how stem cells and regeneration work in flatworms
This work explores how certain flatworms can regrow any missing body part, hoping to learn how to help people with tissue damage or diseases like cancer.
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New tools to precisely edit and read DNA and gene activity for treating disease
Researchers are building next-generation tools to change and record DNA and gene activity to help people with genetic diseases and cancer get safer, more targeted care.
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Understanding how early cells develop and behave in mice
This study is looking at how certain early cells in mice work together to build different tissues, using new technology to track their behavior, which could help us understand normal development and diseases like cancer better, and possibly lead to new treatments.
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Understanding how gene regulation works in mammalian cells
This study is looking at how certain proteins and RNA work together to help control gene activity in our cells, focusing on a special type of RNA that might influence these processes, and it's for anyone interested in understanding how our genes are regulated for better health.
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Using KRAS inhibitors to help the immune system destroy cancer cells
This study is looking at how combining two treatments—KRAS inhibitors and anti-CD47 antibodies—can help boost the immune system to better fight KRAS mutant cancers, aiming to find a more effective option for patients who have few choices right now.
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Understanding how germ cells maintain their unique identity
This study is looking at how special cells called germ cells keep their unique abilities to become any type of cell in the body, which could help us understand more about their role in health and development.
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Understanding how cells divide accurately
This study is looking at how certain parts of our cells work together to make sure they divide correctly, which is important for keeping our bodies healthy, and it's using human cells to understand these processes better.
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Understanding how microRNAs regulate neuron function
This study is looking at tiny molecules called microRNAs that help control how genes work in brain cells, and it's for anyone interested in understanding how our brains adapt and change based on our experiences.
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Understanding how adult stem cells maintain their identity and function
This study looks at how adult stem cells in fruit flies can both make new specialized cells and keep renewing themselves, helping us understand how these cells work and how they might help with tissue health.
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Understanding how chronic Toxoplasma infections develop and persist
This study is looking into how a parasite called Toxoplasma gondii causes long-lasting infections, especially in people with weakened immune systems, by focusing on a key player called BFD1 that helps the parasite survive, so we can better understand its effects on health.
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Understanding how Toxoplasma gondii maintains chronic infection
This study is looking at how a common parasite called Toxoplasma gondii stays in the body for a long time and how two important proteins help it do that, with the hope of finding new ways to help people, especially those with weak immune systems, avoid serious health issues from this infection.
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How maternal organelles affect the health of offspring germ cells
This study looks at how tiny structures from a mother fruit fly can affect the health of her offspring's reproductive cells, helping us understand how these important parts are passed down and maintained during development.
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Using cell-derived particles to deliver therapeutic molecules
This study is exploring new ways to help deliver important treatments like proteins and RNAs into cells, which could lead to better and safer therapies for different diseases by improving how we produce tiny particles that carry these treatments.
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Understanding how tumors and immune cells interact during cancer treatment
This study is looking at how cancer tumors and immune cells work together during treatments that help boost the immune system, with the hope of finding better ways to help patients respond to cancer therapies.
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Understanding how small molecules called polyamines affect cell functions
This study is looking at tiny compounds called polyamines that help our cells grow and stay healthy, and it aims to find better ways to measure these compounds in living cells to understand how they might affect diseases like cancer and genetic disorders, which could lead to new treatments.
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Understanding how signaling proteins communicate in animal development
This study looks at how certain proteins help cells talk to each other during animal development, which is important for making sure tissues are organized correctly, and it could help us understand problems that arise when this communication goes wrong.
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Understanding how DNA modifications affect plant development
This study looks at how changes to DNA in the plant Arabidopsis thaliana help control its growth and development, which could teach us more about how similar processes work in other living things.
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Understanding how planarians regenerate body parts
This study is exploring how planarians, a type of flatworm that can regrow lost body parts, use special stem cells to decide what to regenerate, which could help us learn more about healing and regeneration in humans.
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Investigating how a tiny fish brain can regenerate nervous system functions
This study is looking at a tiny fish to learn how some animals can heal their nervous systems after injuries, which could help us find new ways to treat brain injuries and diseases in people.
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Understanding how germ cells maintain their identity
This study is looking at how special cells called germ cells, which can turn into any type of cell in the body, keep their unique identity throughout a person's life, and it aims to help us understand how these cells stay healthy and support fertility for future generations.
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Understanding how certain proteins help parasites invade host cells
This study is looking at how certain parasites, like those that cause malaria and toxoplasmosis, get into our cells, and it’s trying to find new ways to help treat these infections by understanding the proteins that help them invade.
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Understanding how hibernation-like states can help improve human health
This study is looking at how some animals can slow down their body functions during hibernation and how understanding this could help us find new ways to treat health problems like cancer and metabolic diseases in people.
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