Post-transcriptional gene regulation in human cells
Official title: Post-transcriptional gene regulation
Funded at Whitehead Institute for Biomedical Res · NIH-11329480 · Data updated 2026-11-12
A grant studying how microRNAs control which genes are turned on or off in human cells, with a focus on cancer and development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Whitehead Institute for Biomedical Res NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 1, 2016 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,781,795 |
| NIH project number | 2R35GM118135-11 |
| Project ID | NIH-11329480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose cancers or developmental disorders are linked to microRNA pathways or gene regulation abnormalities.
✕Less likely to help
Patients with conditions not driven by microRNA regulation may not directly benefit from this basic research.
What this research studies
This project looks at how small RNA molecules called microRNAs influence which mRNAs get degraded or translated into proteins in human cells. Researchers aim to understand how microRNA-target recognition works and to develop better ways to predict which targets are repressed. They will also explore microRNA regulatory mechanisms, including processes in neurons and how microRNA-guided mRNA slicing occurs. Additionally, the work investigates a cellular pathway that degrades specific microRNAs, hoping to map its biological roles and relevance to human diseases. The goal is to build resources and methods that help many scientists study microRNAs in human health and disease.
Why it matters
Potential benefit: Better understanding of microRNA biology could lead to new approaches to diagnose or treat cancers and other human diseases.
How similar studies have gone: Similar work has advanced knowledge of microRNA biology and improved predictive methods, with translational potential.
Where this research is happening
-
Whitehead Institute for Biomedical Res
Cambridge, United States Active
Researchers
- Principal investigator: Bartel, David P — Whitehead Institute for Biomedical Res
- Study coordinator: Bartel, David P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.