Understanding how gene regulation works in mammalian cells
Official title: Transcriptional regulation in mammalian cells
Funded at Whitehead Institute for Biomedical Res · NIH-11093980 · Data updated 2026-11-12
This study is looking at how certain proteins and RNA work together to help control gene activity in our cells, focusing on a special type of RNA that might influence these processes, and it's for anyone interested in understanding how our genes are regulated for better health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Whitehead Institute for Biomedical Res NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | July 20, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $798,507 |
| NIH project number | 5R35GM144283-04 |
| Project ID | NIH-11093980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression and regulation, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to transcriptional regulation or those not affected by gene expression issues may not benefit from this research.
What this research studies
This research investigates the process of transcription, which is crucial for maintaining healthy cell functions. It focuses on how large assemblies of proteins and RNA, known as biomolecular condensates, regulate gene expression. The study aims to explore the role of long noncoding RNAs in influencing these condensates and how their dynamics affect nearby genes. By examining the interactions and behaviors of these molecules, the research seeks to uncover new insights into gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene regulation errors.
How similar studies have gone: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
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Whitehead Institute for Biomedical Res
Cambridge, United States Active
Researchers
- Principal investigator: Young, Richard — Whitehead Institute for Biomedical Res
- Study coordinator: Young, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.