Understanding how gene regulation affects pancreatic cancer
Official title: Mechanisms of gene expression regulation in pancreatic cancer
Funded at Whitehead Institute for Biomedical Res · NIH-11159867 · Data updated 2026-11-12
This study is looking at how changes in genes and their regulation affect pancreatic cancer, with the goal of finding new ways to treat this tough disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Whitehead Institute for Biomedical Res NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 9, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $103,639 |
| NIH project number | 4K00CA284259-03 |
| Project ID | NIH-11159867 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or those at high risk for developing this cancer.
✕Less likely to help
Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the complex mechanisms of gene expression regulation in pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of cancer. By examining the roles of genetic mutations and epigenetic changes, the study aims to uncover how these factors contribute to cancer transformation. Using advanced techniques like ChIP-seq and RNA-seq, researchers will analyze chromatin organization and the behavior of specific proteins involved in gene regulation. This work seeks to identify potential new targets for treatment by understanding the molecular processes that drive PDAC progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pancreatic cancer.
How similar studies have gone: Other research has shown promise in understanding gene regulation in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Whitehead Institute for Biomedical Res
Cambridge, United States Active
Researchers
- Principal investigator: Pease, David R — Whitehead Institute for Biomedical Res
- Study coordinator: Pease, David R
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.