Understanding how microRNAs regulate neuron function
Official title: Mechanisms governing post-transcriptional regulation of neuronal microRNAs
Funded at Whitehead Institute for Biomedical Res · NIH-11067728 · Data updated 2026-11-12
This study is looking at tiny molecules called microRNAs that help control how genes work in brain cells, and it's for anyone interested in understanding how our brains adapt and change based on our experiences.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Whitehead Institute for Biomedical Res NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $78,892 |
| NIH project number | 5F32MH134541-02 |
| Project ID | NIH-11067728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who may be experiencing neurological conditions or cognitive impairments.
✕Less likely to help
Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of microRNAs in controlling gene expression within neurons, focusing on how these molecules can rapidly influence protein production. By examining post-transcriptional regulation, the study aims to uncover mechanisms that allow neurons to adapt and change in response to experiences. The research employs advanced techniques like crosslinking and immunoprecipitation sequencing to identify specific microRNAs and their targets, which could provide insights into neural plasticity and brain function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain function and treating neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding microRNA functions in neural plasticity, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Whitehead Institute for Biomedical Res
Cambridge, United States Active
Researchers
- Principal investigator: Frank, Michelle — Whitehead Institute for Biomedical Res
- Study coordinator: Frank, Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.