Understanding how microRNAs regulate neuron function
Mechanisms governing post-transcriptional regulation of neuronal microRNAs
['FUNDING_FELLOWSHIP'] · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · NIH-11067728
This study is looking at tiny molecules called microRNAs that help control how genes work in brain cells, and it's for anyone interested in understanding how our brains adapt and change based on our experiences.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WHITEHEAD INSTITUTE FOR BIOMEDICAL RES (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11067728 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microRNAs in controlling gene expression within neurons, focusing on how these molecules can rapidly influence protein production. By examining post-transcriptional regulation, the study aims to uncover mechanisms that allow neurons to adapt and change in response to experiences. The research employs advanced techniques like crosslinking and immunoprecipitation sequencing to identify specific microRNAs and their targets, which could provide insights into neural plasticity and brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who may be experiencing neurological conditions or cognitive impairments.
Not a fit: Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain function and treating neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding microRNA functions in neural plasticity, indicating that this approach has potential for significant discoveries.
Where this research is happening
CAMBRIDGE, UNITED STATES
- WHITEHEAD INSTITUTE FOR BIOMEDICAL RES — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANK, MICHELLE — WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
- Study coordinator: FRANK, MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.