Sponsor or institution
Clinical trials and research at University of Texas Dallas
As of November 12, 2026, Find a Trial lists 166 NIH-funded research projects at this institution, with $84.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 166NIH research projects
NIH-funded research (newest 40 of 166)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Profilin as a Target to Normalize Tumor Vessels in Kidney Cancer
A new approach aims to curb blood vessel growth in a common kidney cancer by targeting a protein called Profilin 1 to improve how blood vessels form in tumors.
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Ultrafast debinding for chairside 3D-printed zirconia dental restorations
A new ultrafast debinding method aims to dramatically shorten how quickly chairside 3D-printed zirconia dental crowns can be made.
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Adolescents learning about themselves through friends and how it links to mood
A study with teens will test how feedback from close friends and strangers shapes their self-views and mood, using brain and behavior measurements.
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Bilingual children with developmental language disorder: how two languages shape brain development
A study with bilingual kids who have developmental language disorder to see how knowing two languages affects their brain and language skills.
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BET inhibitors as a potential therapy for solitary fibrous tumor (SFT)
Aimed at adults with solitary fibrous tumor, this grant explores BET inhibitors to block tumor-driving gene activity.
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Estrogen, puberty, and early signs of psychosis in teens
This grant looks at how rising estrogen during puberty in girls may influence early brain changes and psychotic-like experiences as kids become teens.
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Social Cognition Measures for People at Risk of Psychosis
A study to find and test the best mental tasks that measure social thinking for people who might develop psychosis.
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Quick bilingual language screener for Spanish-English and Mandarin-English toddlers
A fast, tablet-based screen tool helps identify language development needs in bilingual toddlers (ages 24–36 months) who speak Spanish-English or Mandarin-English.
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Affective forecasting to slow down impulsive choices in adults
A research project tests whether imagining how you will feel about future rewards can help people across adulthood, including those affected by Alzheimer’s, make healthier long-term choices.
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Vagus nerve therapy to reduce liver inflammation in alcohol-related liver disease
A researchers team is testing whether stimulating the vagus nerve can lower liver inflammation and damage in people or animals with alcohol-related liver disease.
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Gut microbiome targets to ease sickle cell pain in patients
Researchers are studying how gut microbes affect chronic pain in people with sickle cell disease and how penicillin prophylaxis in babies might change pain pathways.
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Fullwave physics-guided ultrasound modeling for faster, clearer imaging
A patient-friendly project to make ultrasound images more accurate and reliable by using advanced computer models that simulate how ultrasound waves move through body tissues.
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USENSE: a quick urine test that detects bacteria and inflammation at the point of care
A new handheld test aims to rapidly identify urinary tract infections by measuring both the bacteria and the body's inflammatory response in urine.
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Neural bases of sound sensitivity in children
A pediatric-focused study aims to find objective markers of why some children have extremely sensitive hearing to everyday sounds.
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Blood-brain barrier problems during bacterial meningitis
Researchers are studying why the brain’s protective barrier fails during bacterial meningitis and how that leads to brain injury, with a focus on how bacteria invade brain cells and disrupt protective transporters.
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Modeling how cells regulate non-genetic variability in human cells
Aims to understand how random differences between cells affect things like stem cell decisions and cancer cell behavior, using math models and experiments in human cell systems.
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Vagus nerve stimulation to help people walk again after spinal cord injury
A new therapy combines targeted vagus nerve stimulation with walking-focused rehab to help people regain gait after spinal cord injury.
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Data Core for a Molecular Encyclopedia of Pain-Related Genes and Cells
A research core at UT Dallas will build data infrastructure and user-friendly tools to organize and share pain-related gene and cell information from human nervous tissues.
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Tissue collection and processing core for human dorsal root ganglia and spinal tissue
This grant funds a tissue core that obtains and processes human dorsal root ganglia and spinal tissue to support pain research and therapeutic discovery.
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Mechanistic insights into chronic low back pain using patient tissues
Researchers are studying nerve and tissue changes in people with chronic low back pain who are having spine surgery to find new clues that could lead to better treatments.
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Mapping how human pain-sensing nerves and spinal cord work at the cellular level
This grant studies how human pain-sensing nerves (DRG) and the spinal cord differ from animals, aiming to map cell types and gene activity in adults with and without chronic pain to inform future therapies.
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Administrative Core supports PRECISE Centers collaboration
A central administrative team across three institutions helps coordinate a large, multi-site research effort focused on advancing understanding of pain in humans.
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Human pain pathway map for better treatments
A national team is studying human pain pathways by analyzing single-cell RNA profiles from human dorsal root ganglia and spinal cord to uncover why some people develop chronic pain.
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Memory networks in kids: how children remember past experiences
A study in children and young people uses brain recordings to understand how memory retrieval works across development.
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Understanding why hearing loss affects women differently
This project looks at why hearing loss happens more in women and how menopause and immune factors might play a role, with the goal of better tools to identify and treat it.
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Understanding how epigenetic switches work in human cells
A mathematical and computational study in human cells aims to map how epigenetic changes control gene activity, using CRISPR-based tools to build and study programmable regulatory circuits.
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Multifunctional ionic liquids to protect implants and promote healing
A study to test a special coating for dental implants that fights infection, reduces inflammation, and helps tissues heal around the implant.
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Molecular links between metabolism and viral infection in latent and active herpesvirus life cycles
This grant studies how viruses change cellular metabolism during latent and active infection to understand what keeps cells alive and infected.
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Amygdala lateralization and bladder pain: how brain sides affect pain and distress
Researchers are studying how the left vs right amygdala in the brain influences bladder pain and related emotions to help people with chronic pelvic pain.
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Engineering platelets for therapeutic use in disease
Researchers are exploring how to safely modify platelets so they can carry treatments to diseased tissues, including Alzheimer’s disease.
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Chemoenzymatic strategies to find and make complex peptides
A funded project at UT Dallas is exploring new ways to create and test nature-inspired macrocyclic peptides that can precisely modulate biomolecular interactions and enable new biocatalytic methods for making complex molecules.
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Postoperative recovery: how pain, delirium, and brain inflammation are linked
A study exploring how immune cells in the body and brain influence recovery after surgery, especially pain and delirium, to help patients recover faster.
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Targeting a molecular stress pathway to relieve diabetic nerve pain
A researcher at UT Dallas is testing whether blocking a cellular stress pathway can reduce nerve pain caused by diabetes.
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Central modulation-paired motor rehabilitation for RLN injury in the larynx
Aimed at people with recurrent laryngeal nerve injury, this project tests a central nervous system approach to restore vocal fold movement and improve swallowing and voice.
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Dopamine, brain aging, and neuroplasticity in longitudinal cognitive change
A long-term study following adults as they age to understand how dopamine, brain changes, and neuroplasticity relate to cognitive aging.
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How a peripheral enzyme (NAAA) affects the development of long-term pain
Looking at whether blocking a peripheral enzyme called NAAA could stop short-term pain from becoming long-lasting in adults.
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Genetic clues to defensin signaling in urinary tract infections
Scientists will study how defensins, tiny immune molecules, help fight urinary tract infections in a mouse model to uncover new ways to treat UTIs.
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Understand PAR2’s role in human pain with a humanized approach
A research project is exploring how PAR2 receptors contribute to pain in humans and whether targeting PAR2 could relieve pain from conditions like arthritis.
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Socioeconomic factors shaping brain health and cognitive aging in midlife
A long-term study of how health, lifestyle, and environment in midlife influence brain aging and the risk of cognitive decline, especially in people at higher risk for Alzheimer's disease.
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Noninvasive Acoustic Brain Oxygen Imaging for Neonatal Care
A new ultrasound-based method aims to monitor brain oxygen use in newborns with hypoxic injury using tiny oxygen-sensitive bubbles.
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