Understand PAR2’s role in human pain with a humanized approach
Official title: A Humanized Approach to Understanding PAR2 in Pain and Migraine
Funded at University of Texas Dallas · NIH-11366810 · Data updated 2026-11-12
A research project is exploring how PAR2 receptors contribute to pain in humans and whether targeting PAR2 could relieve pain from conditions like arthritis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | July 1, 2016 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $617,958 |
| NIH project number | 2R01NS098826-06A1 |
| Project ID | NIH-11366810 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with acute or chronic pain conditions, especially those involving nociceptor activity and protease signaling.
✕Less likely to help
Patients without pain related to PAR2 pathways may not directly benefit.
What this research studies
This project uses a humanized PAR2 model to study how PAR2 on sensory neurons influences pain signals, focusing on human neuron behavior and responses to proteases. It combines advanced technologies to compare human and mouse PAR2 signaling and identify potential analgesic targets. The goal is to identify how PAR2 contributes to pain in humans and how blocking it might reduce pain in conditions such as inflammatory or neuropathic pain.
Why it matters
Potential benefit: If successful, the work could lead to new pain-relief strategies that target PAR2 in humans.
How similar studies have gone: Previous work shows PAR2 in human nociceptors may be a key driver of pain, suggesting potential for translation to therapies.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Dussor, Gregory O — University of Texas Dallas
- Study coordinator: Dussor, Gregory O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.