Identifying molecular signs of imprinting errors linked to fertility treatments
Official title: Identifying Molecular Signatures of Genomic Imprinting Errors
Funded at University of Pittsburgh at Pittsburgh · NIH-11667742 · Data updated 2026-11-12
This grant studies how assisted reproductive technologies may cause imprinting errors in embryos and how these errors relate to certain birth conditions, with implications for families using infertility treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $119,044 |
| NIH project number | 6R01HD101574-06 |
| Project ID | NIH-11667742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants include families and embryos affected by ART and children with imprinting-related conditions.
✕Less likely to help
Results may not immediately benefit individuals not undergoing ART or without imprinting-related concerns.
What this research studies
If you or your child were affected by infertility treatments, this project looks at how ART procedures might influence DNA imprinting in early development. Researchers will examine embryos and maternal transcripts to understand why imprinting errors happen after ART. The work aims to uncover biological markers that could predict or prevent these issues in future pregnancies. Findings could guide safer ART practices and improve outcomes for children conceived with these technologies.
Why it matters
Potential benefit: Better understanding of how ART affects imprinting could lead to safer fertility treatments and healthier pregnancies for families using ART.
How similar studies have gone: Previous animal studies suggest ART can impact imprinting, but human data are still limited; this project builds on emerging but not yet conclusive evidence.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Mann, Mellissa Rae Wigle — University of Pittsburgh at Pittsburgh
- Study coordinator: Mann, Mellissa Rae Wigle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.