Promoting and Visualizing Immune Regulation to Protect Transplants
Official title: Promoting and Visualizing Immune Regulation in Transplantation
Funded at University of Pittsburgh at Pittsburgh · NIH-11520406 · Data updated 2026-11-12
A cutting-edge study looks for ways to prevent chronic rejection and help transplanted organs survive longer by boosting the body’s regulatory immune processes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | June 13, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $84,072 |
| NIH project number | 3U01AI170074-05S1 |
| Project ID | NIH-11520406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people awaiting or living with organ transplants who would benefit from therapies that promote immune tolerance.
✕Less likely to help
Patients not experiencing issues with chronic rejection or those not suitable for immune-modulating approaches may see limited benefit.
What this research studies
This project aims to improve long-term transplant success by targeting innate immune memory and enhancing regulatory immune cells. Researchers will use genetic methods and new approaches to strengthen myeloid regulatory cells and regulatory T cells to support tolerance. The work focuses on how innate immune memory interferes with immune regulation and whether inhibiting it can create a lasting, protective environment for the graft. The study is designed to translate these findings into strategies that could reduce the need for lifelong heavy immunosuppression.
Why it matters
Potential benefit: If successful, this could lead to better graft survival with fewer side effects from current drugs.
How similar studies have gone: Earlier work suggests manipulating regulatory cells can influence transplant tolerance, but this approach explores a novel link with innate immune memory.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Camirand, Geoffrey — University of Pittsburgh at Pittsburgh
- Study coordinator: Camirand, Geoffrey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.