Multi-Trait Genetic Analysis Using Large Biobank Data Linked to Health Records
Official title: Multi-Trait Analysis in Large-Scale Biobank Datasets Linked to Electronic Health Records.
Funded at University of Pittsburgh at Pittsburgh · NIH-11607167 · Data updated 2026-11-12
Researchers will develop new genetic methods to better predict disease risk by combining large biobank data with electronic health records.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HG013546-03 |
| Project ID | NIH-11607167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals whose data are included in large biobanks linked to electronic health records and whose diseases are being studied.
✕Less likely to help
Patients outside the studied diseases or those not represented in the biobanks may not directly benefit.
What this research studies
This project uses huge sets of health records and biomarkers to model disease risk more accurately. It will create locus-aware approaches that consider how different genetic regions contribute to multiple related traits, improving interpretation of genetic findings. The work focuses on improving cross-biobank consistency and the accuracy of polygenic risk predictions to help clinicians and patients in the future.
Why it matters
Potential benefit: Could lead to more accurate genetic risk scores and better-tailored prevention strategies for patients.
How similar studies have gone: Initial results from related multi-trait genomic studies show promise but cross-biobank transferability remains a challenge, making this approach novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Lee, Hyunkyu — University of Pittsburgh at Pittsburgh
- Study coordinator: Lee, Hyunkyu
Related research
Other NIH-funded projects on the same topics.
-
Elastomeric membranes for safer pelvic organ prolapse repair
A new 3D-printed elastomeric membrane made from polycarbonate urethane is being tested to replace stiff polypropylene meshes for pelvic organ prolapse in women, aiming to reduce complications.
-
Role of hyaluronan in egg development and ovarian reserve
This grant studies how the hyaluronan matrix in the ovary affects the aging of the female reproductive system and the pool of eggs available.
-
Regulatory switches that control imprinting in early human development
This grant studies how certain genes stay “one-copy” active in early development and what goes wrong in assisted reproduction, with a focus on imprinting disorders.
-
Identifying molecular signs of imprinting errors linked to fertility treatments
This grant studies how assisted reproductive technologies may cause imprinting errors in embryos and how these errors relate to certain birth conditions, with implications for families using infertility treatments.
-
Bioadhesive vaginal film for 7-day protection against HIV, HSV, and pregnancy
A vaginal film that slowly releases antibodies to prevent HIV, HSV, and unintended pregnancy for about a week from a single use.
-
Spermatogonial stem cell transplantation and culture in patients
Researchers are testing a way to transplant or grow sperm-producing cells back in boys and men who stored tissue before cancer treatment, to help them have biological children in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.