Sponsor or institution

Clinical trials and research at University of Notre Dame

• 7Clinical trials
• 137NIH research projects
• 2Countries

Newest trials

All recruiting trials (7)

• See if the Common Elements Treatment Approach helps mothers in Lima improve mental health and parenting

  This trial tests whether the Common Elements Treatment Approach (CETA) can improve mental health and parenting outcomes for mothers of young children in a low-income community in Lima, Peru.

  Recruiting Phase 2 University of Notre Dame · Lima · NCT07667738

• Brief alcohol-focused program tailored for people taking buprenorphine

  This project will try a short, opioid-informed alcohol counseling program for adults on prescribed buprenorphine who drink alcohol to see if it reduces drinking and helps them stay in treatment.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07342504

• Restoring everyday health and wellbeing by improving sleep

  This study will try Cognitive Behavioral Therapy for Insomnia (CBT-I) in adults with chronic insomnia to see if better sleep changes stress-hormone (cortisol) patterns and improves daytime health, especially for people who sleep less than six hours a night.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07156383

• Family support program for parents and children in Palestine

  This study is testing a family support program to see if it can help parents and their teenagers in Palestine feel safer and improve their relationships after experiencing conflict.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT05706376

• A program to improve family communication and resolve conflicts

  This study is testing a program to help families communicate better and resolve conflicts, comparing a self-study approach with coaching to a more interactive option with video sessions.

  Recruiting at 3 sites University of Notre Dame · Fort Wayne, Indiana and 2 other locations · NCT04980794

• Evaluating a new brush for treating blepharitis

  This study is testing a new brush combined with a regular eyelid cleanser to see if it helps people with blepharitis feel better and reduce dry eye symptoms.

  Recruiting at 3 sites University of Notre Dame · Boulder, Colorado and 2 other locations · NCT04603222

• Intervention program for families with a child who has developmental disabilities

  This study is testing a program that helps families with a child who has developmental disabilities by providing support and skills to improve their relationships and reduce stress.

  Recruiting University of Notre Dame · Fort Wayne, Indiana and 1 other locations · NCT03495440

NIH-funded research (newest 40 of 137)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Designer covalent blockers to stop IgE-driven allergic reactions

  A new approach aims to block IgE antibodies that trigger allergic reactions in people with allergic asthma, potentially reducing severe symptoms without broad immune suppression.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11551489

• A life-course view of how early adversity shapes health as people grow up

  This NIH grant looks at how tough experiences in childhood and adolescence affect health and aging later in life, using data from people and animal studies to understand why some outcomes are worse and how social factors can help.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11530239

• How a simple, evidence-based approach helps mothers and kids in Peru feel better

  A study tests a flexible, lay-delivered mental-health program called CETA for mothers of young children in Lima to improve family well-being.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11474425

• Open-Source tools to test conversational AI for dementia care

  A multilingual AI benchmarking project aims to help improve chatbots and virtual assistants used in Alzheimer’s and related dementias, with open tools and datasets for researchers and clinicians.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11447548

• Decoding how human CD8+ T cells recognize donor HLA in transplant rejection

  This project studies why certain T cells attack transplanted kidneys, with the goal of understanding which cells drive acute rejection and how they recognize donor HLA.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11443901

• Targeted antibody-guided nanoparticles to treat CMV infection

  A new treatment approach combines CMV-targeting antibodies with drug-loaded nanoparticles to deliver antiviral medicine directly to infected cells, aiming to improve efficacy and reduce side effects for people with CMV infection.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11439626

• Immune cells that help the spinal cord repair

  Researchers are learning how certain immune cells support spinal cord healing to help adults with spinal cord injuries.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11416966

• CETA for mothers and children in Peru: how it helps families over time

  A program called CETA is being tested with mothers of young children in Lima, Peru to see if it helps both moms and kids in the long run.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11415639

• ChemoPAD: a quick test to spot bad quality chemotherapy drugs for cancer care

  A low-cost, point-of-use test and phone app will help protect cancer patients by detecting fake or substandard injectable chemotherapy drugs.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11408729

• Computational biomechanics of inflammation in tissues

  A computer-based project uses math and biology to model how inflammation and swelling occur in living tissues.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11404982

• Glucose-responsive insulin that works for a week

  A researcher is developing a single-injection insulin that can regulate itself for up to a week based on your blood sugar levels to help people with adult-onset diabetes.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11403862

• Immune mechanome: how tissue forces shape immune cells

  A researcher at Notre Dame is studying how physical forces in diseased tissues influence immune cells and their responses.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11400354

• Targeting Gram-Negative Bacteria for New Antibiotic Strategies

  Researchers are exploring how the bacterial cell wall is built and recycled in order to find new ways to stop hard-to-treat Gram-negative infections.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11392250

• Molecular guides for targeting protein loops with covalent molecules

  A new plan to learn how tiny covalent drugs can bind protein loops to control disease-related signals.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11391353

• pH-driven switching of ESX-1 substrates in tuberculosis-related bacteria

  Researchers are studying how the ESX-1 system in pathogenic mycobacteria changes what it secretes when the bacteria encounter different acidity levels, to understand how the bacteria escape macrophages.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11391282

• Understanding fungal CAUTI in catheters and how the bladder fights back

  A researcher at Notre Dame is studying how the fungus Candida albicans causes infections in people with urinary catheters and how the bladder's immune system responds.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11390738

• Endothelin signaling and neural stem cells in brain repair

  Aiming to understand how a brain signal called Endothelin-1 helps neural stem cells stay quiet or become cells that repair myelin after injury.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11386721

• New insights into extracellular signaling by cell vesicles in bacterial infections

  A study looking at how tiny cell fragments called extracellular vesicles communicate signals during bacterial infections, which could reveal new ways to diagnose or treat infections.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11378580

• Preventing child maltreatment by supporting pregnant women and early childhood relationships

  A multi-site trial tests programs delivered during pregnancy and when children are ages 3–6 to reduce child maltreatment and promote healthier parent-child bonds.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11374546

• Understanding how bacteria and fungi interact to cause catheter-related urinary infections

  Researchers are studying how common bladder infections linked to catheters happen when bacteria and fungi work together, and what that could mean for better prevention and treatment.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11373077

• Targeting biofilm to boost antibiotics against Mycobacterium infections

  Aims to find compounds that stop biofilm formation in Mycobacterium avium and M. abscessus to improve how well antibiotics work for people with lung diseases.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11371311

• Targeted eye medicine to protect vision in glaucoma and steroid-induced glaucoma

  A new eyedrop medicine that blocks a protein (Grp94) to improve fluid drainage in the eye and lower eye pressure in glaucoma patients.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11370682

• Developing Youth Resilience to Neighborhood Challenges

  A program to understand how kids and young adults build resilience when they grow up in tough neighborhood conditions, looking beyond mental health to social, emotional, and academic strengths.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11370664

• A bioengineered platform to make smart exosomes for delivering cancer drugs

  A NIH grant is funding a platform to produce and engineer exosomes that can carry cancer drugs directly to tumors, potentially improving treatment.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11364097

• Targeted cancer drugs that block key kinases for AML and TNBC

  Researchers are developing new, single-step synthesized kinase inhibitors aimed at tackling acute myeloid leukemia and certain tough breast cancers.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11359718

• Finding molecules that mimic T cell targets

  This project builds a computer-and-lab system to find molecules that resemble T cell targets, helping people at risk for acute graft-versus-host disease avoid harmful immune reactions.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11358771

• Isoform-selective Hsp90 inhibitors for prostate cancer therapy and immunotherapy

  A new drug approach targets a specific protein (Hsp90β) in prostate cancer to fight tumors and boost immune therapy.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355612

• Tracking real-time drug resistance in malaria in Africa

  Researchers will map the genetic changes that drive artemisinin resistance in malaria parasites to understand why resistant strains spread in Africa.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355544

• Genetic clues to malaria parasite fitness across mosquito and liver stages

  Researchers are studying how the malaria parasite’s genes affect its ability to survive and move through the mosquito and liver stages, which could influence how drug resistance spreads.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355536

• Peaks to genes: fine mapping of QTLs and functional analysis

  A multi-year project to pinpoint which genes cause important traits by linking DNA differences to traits and testing candidate genes.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355531

• Genetic crosses to map malaria drug resistance in Plasmodium falciparum

  Researchers are using cross-breeding of drug-susceptible and drug-resistant malaria strains to identify genetic factors that drive resistance, with tests in a human-liver mouse model to replace chimpanzees.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355528

• Harnessing genetic crosses to understand malaria drug resistance

  In this project, researchers are studying how malaria becomes resistant to drugs by using genetic crosses and sharing findings openly with researchers worldwide.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355523

• Understanding how malaria parasites evolve drug resistance through genetic crosses

  Scientists are studying how malaria parasites acquire resistance to drugs by crossing parasite strains and mapping the genes involved, with the goal of staying ahead of resistant malaria.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11355521

• Genomic and antibody clues to malaria sources in Ethiopian highlands

  This project looks at malaria parasites and mosquito bites to tell whether malaria cases in the Ethiopian highlands come from local transmission or travel from other regions.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11354692

• Water hyacinth and schistosomiasis: testing a plant-cleaned lake to boost a proven disease control method

  A short, patient-friendly description of a grant that tests how removing water hyacinth from Lake Victoria might help reduce schistosomiasis using a proven intervention that also creates economic benefits.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11354684

• Pick’s disease tau forms studied with stapled proteins

  A small NIH grant is funding scientist-led work to create stable 3R tau protein mimics from Pick’s disease to understand how this rare brain condition starts and spreads.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11353455

• Blocking C. difficile spore germination to prevent recurrent infection

  Aims to test a new class of antibiotics that stop C. difficile spores from germinating, helping people with recurrent infections.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11338642

• Targeting the bacterial cell wall recycling to fight Pseudomonas infections

  Aims to block how the bacteria recycle its wall materials in Pseudomonas aeruginosa to help restore effectiveness of common antibiotics.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11338213

• Stopping immune-suppressing neutrophils to help treat metastatic breast cancer

  Researchers are exploring whether blocking a neutrophil protein called Acod1 can weaken immune-suppressing neutrophils and make immunotherapy work better for people with metastatic breast cancer.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11324967

• Engineered aging environment to study cancer and drug responses

  Aims to create aging-themed 3D tumor models using aged human tissue and cells to better study how aging affects cancer growth and treatment responses.

  NIH research University of Notre Dame · Notre Dame, United States · NIH-11323957

Quick answers

How many clinical trials run by University of Notre Dame are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (6 trials), Peru (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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