Endothelin signaling and neural stem cells in brain repair
Official title: Endothelin signaling in neural stem cell homeostasis and remyelination
Funded at University of Notre Dame · NIH-11386721 · Data updated 2026-11-12
Aiming to understand how a brain signal called Endothelin-1 helps neural stem cells stay quiet or become cells that repair myelin after injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | August 6, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $424,106 |
| NIH project number | 5R01NS140152-02 |
| Project ID | NIH-11386721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with demyelinating brain conditions or healthy adults for baseline cellular studies using human-derived cells or tissues.
✕Less likely to help
People without demyelinating conditions may not directly benefit from this basic mechanistic work.
What this research studies
This project looks at how blood vessel signals influence neural stem cells in the adult brain, especially after demyelination. Researchers will use mouse models and cell culture to see if Endothelin-1 keeps stem cells in a dormant state or prompts them to make myelin-producing cells. The work will examine neurovascular interactions in the stem cell niche and how they change during repair. Findings could reveal new ways to promote brain repair by targeting Endothelin-1 signaling.
Why it matters
Potential benefit: If successful, the work could uncover mechanisms to enhance remyelination and brain repair in conditions like multiple sclerosis or traumatic injury.
How similar studies have gone: Previous work showed Endothelin-1 influences neural stem cells during development; this study tests its role in the adult brain and disease models.
Where this research is happening
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University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Adams, Katrina L — University of Notre Dame
- Study coordinator: Adams, Katrina L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.