Computational biomechanics of inflammation in tissues
Official title: Computational Biomechanics Modeling of Inflammation
Funded at University of Notre Dame · NIH-11404982 · Data updated 2026-11-12
A computer-based project uses math and biology to model how inflammation and swelling occur in living tissues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | September 21, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $391,250 |
| NIH project number | 5R35GM147029-05 |
| Project ID | NIH-11404982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory conditions or diseases involving tissue swelling could indirectly benefit from improved diagnosis and therapies informed by these models.
✕Less likely to help
Direct patient participation is not described; the work is computational and mechanistic.
What this research studies
This grant funds a project at Notre Dame that builds computer models to understand how mechanical forces and inflammatory cells interact in swollen tissues. The team will allow cell behavior to vary by location, time, and cell type, and will simulate how tissue mechanics constrain or drive swelling during inflammation. The goal is to better explain how inflammation develops and affects tissue function so doctors can interpret signs of disease more accurately. The work blends mechanics, computation, and biology to explore how physical forces influence disease processes.
Why it matters
Potential benefit: If successful, this modeling approach could improve diagnosis and treatment planning by revealing how inflammation alters tissue mechanics.
How similar studies have gone: Similar computational approaches have provided new insights into tissue mechanics, but applications to inflammation are an active area with potential for novel findings.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Holland, Maria — University of Notre Dame
- Study coordinator: Holland, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.