New insights into extracellular signaling by cell vesicles in bacterial infections
Official title: New insights into extracellular signal transduction
Funded at University of Notre Dame · NIH-11378580 · Data updated 2026-11-12
A study looking at how tiny cell fragments called extracellular vesicles communicate signals during bacterial infections, which could reveal new ways to diagnose or treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $328,650 |
| NIH project number | 5R01GM148708-04 |
| Project ID | NIH-11378580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients with bacterial infections where EV signaling might play a role or individuals from whom infection-related samples are or could be obtained for research.
✕Less likely to help
Individuals without access to infection-related samples or without bacterial infection involvement may not directly benefit.
What this research studies
This project explores how cells communicate with each other through extracellular vesicles and how this signaling may influence bacterial infections. Researchers will examine the composition and functions of these vesicles in both laboratory settings and living organisms to understand their role in disease. The work aims to map how vesicle cargo affects recipient cells and how this knowledge could lead to new diagnostic or therapeutic approaches for infections.
Why it matters
Potential benefit: Understanding EV signaling could lead to novel diagnostics or treatments for bacterial infections.
How similar studies have gone: Previous EV studies have shown informative roles for vesicles, but many hypotheses remain untested, making this a promising but exploratory effort.
Where this research is happening
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University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: D'souza-Schorey, Crislyn — University of Notre Dame
- Study coordinator: D'souza-Schorey, Crislyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.