Peaks to genes: fine mapping of QTLs and functional analysis
Funded at University of Notre Dame · NIH-11355531 · Data updated 2026-11-12
A multi-year project to pinpoint which genes cause important traits by linking DNA differences to traits and testing candidate genes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | August 1, 2017 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $374,297 |
| NIH project number | 5P01AI127338-08 |
| Project ID | NIH-11355531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient population; this is a basic research project using parasite models and human data for method development.
✕Less likely to help
This project may not directly benefit patients in the short term but could inform future therapies through better gene-targeting approaches.
What this research studies
If you or a loved one has a trait linked to specific genetic regions, this project uses advanced mapping and gene editing to identify the exact genes responsible. It combines sequencing, analysis of genetic crosses, and CRISPR-based methods to prioritize and validate candidate genes that influence traits. The work includes creating long-read reference sequences and developing bioinformatic tools to map QTLs more precisely, with core facilities supporting these analyses. By clarifying which genes drive key traits, the research aims to lay groundwork for future interventions and a deeper understanding of human-related biology.
Why it matters
Potential benefit: Clearer understanding of which genes influence important traits may guide future medical research and therapies.
How similar studies have gone: Previous work has shown that combining bulk segregant analysis with long-read sequencing can successfully map QTLs to specific genes.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Anderson, Tim J — University of Notre Dame
- Study coordinator: Anderson, Tim J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.