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Clinical trials and research at University of Massachusetts, Worcester

• 39Clinical trials
• 1New in 30 days
• 16Countries

Newest trials

All recruiting trials (39)

• Cardiac Arrest: Using Ultrasound to Find Hidden Blood Flow

  This study tests whether patients who have out-of-hospital cardiac arrest but no pulse still show some blood flow on ultrasound and whether that finding relates to survival.

  Recruiting University of Massachusetts, Worcester · Denver, Colorado and 7 other locations · NCT07897370

• Neighborhood Connect: improving Worcester neighborhoods through community action

  Neighborhood Connect tests a community-led approach to make Worcester neighborhoods more attractive, safer, and livable by training residents and collaborating with local health officials.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07780825

• Medically tailored groceries to help depression in people with food insecurity

  This trial tests whether giving medically tailored groceries for six months can reduce depressive symptoms in adults who have depression and struggle with access to food.

  Recruiting at 2 sites University of Massachusetts, Worcester · Worcester, Massachusetts and 2 other locations · NCT07779707

• Helping rural jails use medications for opioid use disorder better

  This project tests a training program to help jail staff in rural areas start or expand medications for opioid use disorder and see if it improves public health outcomes.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07637994

• Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking-Criminal Justice (MISSION-CJ) for re-entry

  This trial tests a multicomponent program called MISSION-CJ with Peer Linkage Support to help adults released from two Massachusetts jails who have both mental health and substance use disorders.

  Recruiting at 2 sites University of Massachusetts, Worcester · Northampton, Massachusetts and 1 other locations · NCT07555145

• Lifestyle change program with GLP-1 medication users

  This trial tests whether the Noom digital lifestyle program helps adults on GLP-1 medications improve eating, activity, and weight-related health.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07481305

• Prehab to get stronger before pancreatic cancer surgery

  This project will test whether adults with pancreatic cancer can follow a combined exercise, nutrition, and symptom-management program during chemotherapy to improve fitness and recovery before surgery.

  Recruiting University of Massachusetts, Worcester · Worester, Massachusetts · NCT07478185

• Reaching Calm: A digital program to help prevent anxiety during pregnancy

  A digital program called Reaching Calm is tested in obstetric clinics to see if it can help prevent anxiety for pregnant people at risk.

  Recruiting University of Massachusetts, Worcester · Leominster, Massachusetts · NCT07458698

• Avatar-guided digital support for emerging adults with binge drinking and suicidal thoughts

  This study tests whether a new avatar-guided digital coach plus texts helps 18–29 year-olds in the emergency department with binge drinking and suicidal thoughts, compared with a standard suicide safety app.

  Recruiting at 2 sites University of Massachusetts, Worcester · Marlborough, Massachusetts and 1 other locations · NCT07418047

• Which vaccine messages grab attention in rural New England

  This online test uses short social-media vaccine messages delivered by either experts or influencers to see which ones better catch attention and influence attitudes among adults living in rural New England.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07236034

• Injecting saline to lower bladder puncture risk during retropubic midurethral sling surgery

  This trial tests whether injecting sterile saline into the retropubic space during retropubic midurethral sling surgery can reduce the chance that the trocar will puncture the bladder for adult women having this procedure.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07208682

• Sustaining and tailoring school-based HIV prevention

  This project will test adaptive support strategies and machine learning to help Bahamian teachers keep an evidence-based HIV prevention curriculum working well for grade 6–9 students and their teachers.

  Recruiting University of Massachusetts, Worcester · Nassau · NCT07153042

• Paramedic home visits for sudden COPD flare-ups (PEACE)

  This program will try sending community paramedics, guided by remote physicians, to treat adults with COPD at home during sudden flare-ups to reduce emergency visits.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT07072039

• WE CARE social needs screening and referral for families in primary care

  This project will test whether using the WE CARE social needs screening and referral program with an antiracist approach in family medicine can help reduce chronic conditions like diabetes, high blood pressure, depression, high cholesterol, and pediatric asthma for minoritized patients.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts and 2 other locations · NCT06903897

• Characterizing pelvic vein flow using advanced MRI techniques

  This study is testing how blood flows in the pelvic veins of healthy people, those with May-Thurner syndrome, and patients with iliac stents to better understand these conditions.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06888024

• Re-Engineered Discharge for Diabetes Care Transitions

  A computer-based screening for social needs and a post-discharge navigator are being tested to help adults with type 2 diabetes after hospitalization see if addressing unmet social needs reduces readmission.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06869057

• Observational study on progressive pulmonary fibrosis and its classification

  This study is trying to better understand and classify progressive pulmonary fibrosis in people with certain lung diseases by following them over two years and collecting their health information and blood samples.

  Recruiting at 9 sites University of Massachusetts, Worcester · Aurora, Colorado and 23 other locations · NCT06855329

• Moms@Home: a storytelling mobile app to help manage blood pressure in pregnancy

  This pilot will test whether the Moms@Home mobile app plus a home blood pressure monitor helps pregnant people with gestational or chronic high blood pressure monitor and manage their blood pressure.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06835959

• Pathways to equitable perinatal mental health care

  This project will test whether a healthcare-only approach or a healthcare-community partnership helps pregnant and postpartum people get better care for depression and anxiety.

  Recruiting University of Massachusetts, Worcester · Shrewsbury, Massachusetts · NCT06790641

• Mothers' Action Project to prevent early tooth decay and reduce obesity risk in young children

  This 12-month program will try group education and social-network support for South Asian mothers with young children to reduce early childhood tooth decay and lower obesity risk.

  Recruiting University of Massachusetts, Worcester · New York, New York · NCT06753669

• Using ShotBlocker to reduce pain during Hepatitis B vaccination in newborns

  This study tests if using the ShotBlocker can help reduce pain for healthy newborns getting their first Hepatitis B vaccine when combined with other comfort techniques.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06624176

• Wearable device for detecting seizures

  This study tests a new wearable device for detecting seizures in people with epilepsy to see if it works well and can help them feel more comfortable in their daily lives.

  Recruiting at 2 sites University of Massachusetts, Worcester · Worcester, Massachusetts and 1 other locations · NCT06598189

• Reducing HIV stigma and improving PrEP use among young transgender women in Thailand

  This study is testing a new program using mobile technology to help young transgender women in Thailand feel more supported and reduce stigma around HIV while encouraging them to use PrEP to stay HIV-negative.

  Recruiting at 3 sites University of Massachusetts, Worcester · Bangkok and 2 other locations · NCT06576648

• Home-based skilled nursing care for rehabilitation

  This study is testing whether home-based nursing care can help people recovering from hospitalization do better than those who go to a rehab facility.

  Recruiting at 2 sites University of Massachusetts, Worcester · Springfield, Massachusetts and 1 other locations · NCT06547645

• Training medical residents in weight management counseling skills

  This study tests a new training program to see if it can help medical residents improve their skills in counseling patients about weight management.

  Recruiting at 7 sites University of Massachusetts, Worcester · Palo Alto, California and 7 other locations · NCT06529666

• Comparing pain relief methods after lumbar fusion surgery

  This study tests whether a new way of giving local anesthesia during lumbar fusion surgery can help patients feel less pain and use fewer opioids compared to the traditional method.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06528288

• School-supervised asthma therapy for children

  This study tests if a school program that helps kids with asthma take their medicine can work better than just giving them an educational workbook, especially for children aged 5-14 who struggle with asthma.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06388460

• Support for low-income mothers of preterm infants

  This study tests if giving financial help to low-income mothers of preterm babies in the NICU can improve their ability to visit and care for their infants, which may lead to better health for both mom and baby.

  Recruiting at 4 sites University of Massachusetts, Worcester · Atlanta, Georgia and 4 other locations · NCT06362798

• Combining poverty alleviation with depression treatment for women in Bangladesh

  This study is testing if helping women in rural Bangladesh with both financial support and depression treatment can improve their mental health more than just treating depression alone.

  Recruiting University of Massachusetts, Worcester · Dhaka, Dhaka Division · NCT06295250

• A Deaf-accessible therapy toolkit for treating alcohol use disorder and trauma

  This study is testing a new therapy toolkit designed for Deaf individuals to see if it helps them better manage alcohol use disorder and trauma compared to standard treatment and no treatment at all.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06278922

• Evaluating a suicide prevention app in emergency departments

  This study tests whether a new app can help people who visit the emergency department for suicidal thoughts by providing support and safety planning compared to standard care.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06223867

• Effects of lumateperone on metabolic side effects in patients taking clozapine for schizophrenia

  This study is testing if adding lumateperone to clozapine treatment can help people with schizophrenia reduce weight gain and cholesterol issues caused by their medication.

  Recruiting Phase 4 University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06174116

• Using botulinum toxin to treat Hidradenitis Suppurativa

  This study is testing if botulinum toxin can help reduce inflammation and improve symptoms in people with Hidradenitis Suppurativa.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT05403710

• Early screening to find gestational diabetes in pregnancy

  This project tries a first-trimester blood screening to see if it finds gestational diabetes earlier in pregnant people at high risk.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT05388643

• Using continuous glucose monitors during pregnancy for women with type 2 diabetes

  This study is testing if using continuous glucose monitors during pregnancy can help women with type 2 diabetes manage their blood sugar better and have healthier babies compared to the usual fingerstick method.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT05317585

• Improving access and recovery for people with opioid use and mental health disorders

  This study is testing a new team approach combined with medication to see if it helps people with both opioid use and mental health issues recover better than just using medication alone.

  Recruiting at 5 sites University of Massachusetts, Worcester · Holyoke, Massachusetts and 4 other locations · NCT05138614

• Observational study on early COPD progression in smokers

  This study is trying to see how early chronic obstructive pulmonary disease (COPD) develops in younger smokers by looking at their health and using scans and tests to find ways to help them sooner.

  Recruiting at 14 sites University of Massachusetts, Worcester · Birmingham, Alabama and 13 other locations · NCT05033990

• Fecal microbiota transplantation for treating recurrent C. difficile infections

  This study is testing whether a stool transplant from a healthy donor can help people with repeated C. difficile infections feel better compared to regular antibiotic treatments.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT03562741

• Repair of complex aortic aneurysms using custom devices

  This study is testing custom-made devices to see if they can safely and effectively treat complex aortic aneurysms in patients who can't use standard options, especially those at high risk or with conditions like Marfan syndrome.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT02050113

Quick answers

How many clinical trials run by University of Massachusetts, Worcester are recruiting right now?

39, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (36 trials), Australia (1 trial), Austria (1 trial), Canada (1 trial), Czechia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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