Reducing HIV stigma and improving PrEP use among young transgender women in Thailand

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to develop a multi-component, technology-delivered intervention that targets HIV and intersectional stigma while enhancing the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative young transgender women aged 18-29 in Thailand. The intervention includes Mobile Healthy Choices (mHC), Finding Respect and Ending Stigma around HIV (FRESH), and standard PrEP counseling. By utilizing mobile health technology, the study seeks to create a supportive environment that encourages PrEP adherence and reduces stigma associated with HIV.

Why it matters

Who can join: the full rules

Aim 1 (Formative Research and Beta-Testing) Transgender women

Inclusion Criteria:

* Ages between 18 and 29 years
* Male sex at birth
* Self-identifies as women, transgender women or culturally identifies with the female spectrum
* Laboratory-confirmed HIV-negative status
* Self-reported recent history of condomless sex
* Able to understand, read and speak Thai
* Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills/week) in the past month.

Exclusion Criteria:

* Have a serious cognitive or psychiatric problem compromising ability to provide informed consent
* Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)
* Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)
* Currently enrolled in another HIV intervention study.

Healthcare providers Inclusion criteria

* Age 18 or above
* Has provided HIV prevention or treatment services for TGW for at least one year Exclusion criteria
* None

Aim 2 (Pilot RCT) Transgender women Inclusion criteria

* Ages between 18 and 29 years
* Male sex at birth
* Self-identifies as women, transgender women or culturally identifies with the female spectrum
* Laboratory-confirmed HIV-negative status
* Self-reported recent history of condomless sex
* Able to understand, read and speak Thai
* Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills/week) in the past month.

Exclusion criteria

* Have a serious cognitive or psychiatric problem compromising ability to provide informed consent
* Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)
* Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)
* Currently enrolled in another HIV intervention study.

Where it's running

• Institute of HIV Research and Innovation
  Bangkok, Thailand Recruiting
• Rainbow Sky Association of Thailand
  Bangkok, Thailand Recruiting
• SWING Foundation
  Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Bo Wang, PhD — University of Massachusetts, Worcester
• Study coordinator: Deogwoon Kim, PhD
• Email: Deogwoon.Kim13@umassmed.edu
• Phone: 586-703-4899

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.