Sponsor or institution
Clinical trials and research at University of Alabama in Tuscaloosa
As of November 12, 2026, Find a Trial lists 54 NIH-funded research projects at this institution, with $23.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 54NIH research projects
NIH-funded research (newest 40 of 54)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Integrated framework to validate and quantify proteoforms in patient-derived ovarian cancer cells
A collaboration will combine advanced top-down proteomics with a new computational method to precisely identify and measure intact proteoforms in tiny samples from ovarian cancer cells.
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Omega-3 fats in diet to calm overactive nerves in adults
A study to see if adding omega-3 rich foods or supplements can reduce nerve hyperactivity and improve neurological symptoms in adults.
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BBTI vs. BMT to improve sleep and thinking in older adults with HIV
This grant tests two sleep-improvement approaches to see which helps older adults with HIV sleep better and think more clearly.
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How aging changes how we respond to viral infections
Aging changes how the body handles viruses, and this project uses fruit flies to understand why older individuals may be more vulnerable to viral infections.
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Tow truck operator safety: preventing struck-by injuries on the road
Aimed at reducing fatalities and injuries among tow truck workers by finding practical ways to prevent drivers from striking them.
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Understanding how bacterial Fe-S clusters are built and regulated
A study to understand how bacteria assemble iron-sulfur clusters and how this process is controlled by protein partners, which could help develop new antibiotics.
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Polyester Particles to Understand How Drugs Move from the Gut to Blood
Researchers are developing tiny polymer particles to improve oral drug delivery and we may one day benefit from better absorption and predictable effects of medicines taken by mouth.
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Unlocking natural products by exploring biosynthetic enzymes
Scientists are studying how natural compounds are built in nature to discover new medicines faster.
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Improving Sleep for Nursing Home Residents with Dementia
A real-world program helps nursing homes use a simple staff approach called LOCK to improve sleep for residents with dementia.
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Mechanisms of nitric oxide in heme enzymes using synthetic mimics
Scientists are studying how nitric oxide interacts with heme enzymes using lab-made models to better understand diseases like autoimmune conditions and cancer.
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Physical activity, endocannabinoids, and decision making in PTSD
A small study will test whether a short bout of exercise changes brain signals and decision-making in adults with PTSD.
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Making roadside work safer for tow truck operators
Trying practical ways to prevent drivers from hitting tow truck workers by looking at what tow operators and passing drivers do on the roadside.
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Improving newborn screening for cystic fibrosis to be more accurate and fair
Develops and compares newborn screening methods to improve detection of cystic fibrosis in newborns, with attention to fairness for African American babies.
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How aging changes the body's response to viruses
This project uses fruit flies to learn how getting older changes interactions between hosts and viruses, with the goal of helping older adults better resist infections.
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Targeted nanoparticle cyclosporine A treatment for lupus
This project develops a tiny, targeted form of cyclosporine A designed to better reach immune tissues and help people with systemic lupus erythematosus.
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Improving how medicines are absorbed through the gut
This project aims to create new materials and tools to help deliver medicines more effectively when taken by mouth.
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Exploring how heme enzymes work and their role in diseases
This study is looking at how certain important enzymes in our body work, using special compounds to mimic them, and the goal is to find new treatment options for conditions like autoimmune diseases and cancer that could help patients feel better.
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Using cold to trigger local anesthesia for pain relief
This study is exploring a new way to help numb pain using a special cold-activated method, which could make getting local anesthesia safer and easier for patients when they need it.
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Improving oral drug delivery using polymer nanoparticles
This study is exploring new ways to help medicines work better when taken by mouth, using tiny particles made from special materials that can help drugs get into your body more effectively, and it's designed for anyone interested in improving how medications are delivered.
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Improving sleep quality for nursing home residents with dementia
This study is testing a new program called LOCK to help nursing home staff create a better sleep environment for residents with Alzheimer's and related dementias, aiming to improve their sleep and overall well-being by reducing noise and light disturbances.
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Exploring enzymes to discover new natural products for drug development
This study is exploring new ways to find natural substances that could help create new medicines by using advanced genetic tools to discover unique compounds made by certain genes, which could lead to exciting new treatments for various health conditions.
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Using urolithin A nanoparticles to treat acute kidney injury
This study is looking at a special treatment using urolithin A, a natural compound that helps protect the kidneys, and testing it in tiny particles to make it work better for people with acute kidney injury.
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How aerobic exercise affects fear learning in PTSD
This study is looking at how different levels of aerobic exercise—light, moderate, or intense—can help people with PTSD feel less anxious and remember things better after therapy, and it also checks how a natural substance in the body might play a role in this process.
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Improving access to hearing healthcare in Alabama
This study is all about making hearing healthcare easier to get for adults in West Central and South Alabama, especially for those who might feel lonely or have trouble thinking clearly because of mild to moderate hearing loss, and it involves the community to find the best ways to help.
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Improving adult outcomes for young adults with autism
This study is testing a program called STEPS to help young people with autism learn important skills for becoming more independent as they transition into adulthood, so they can have better experiences in school, work, and life overall.
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Improving access to hearing aids through pharmacy training in rural areas
This study is looking at how teaching pharmacy workers to help people get over-the-counter hearing aids can make it easier for folks in rural Alabama and Mississippi to access hearing care, especially since there aren't many audiology services available nearby.
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Creating specialized polymers to improve drug delivery through the gut-blood barrier
This study is exploring new tiny particles made from special materials that can help deliver medications more effectively when taken by mouth, aiming to improve how these treatments work in the body for people who need them.
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Helping young children with low empathy notice and respond to others' facial emotions
A computer-based program that gives feedback and small rewards to help young children with callous-unemotional traits better recognize fearful and sad facial expressions.
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Understanding how aging affects interactions between hosts and viruses
This study looks at how getting older affects our body's ability to fight off viruses, especially in older adults, using fruit flies to help understand how their immune systems work differently than younger ones, which could help improve ways to prevent and treat viral infections in seniors.
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Understanding early cognitive decline in individuals with Down syndrome
This study is looking at how thinking skills change in young people with Down syndrome, ages 15 to 25, over three years, to find early signs of cognitive decline that could lead to Alzheimer's disease, so we can help them sooner.
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Understanding how CRISPR-Cas systems recognize and respond to foreign RNA
This study is looking at how a special system in bacteria helps them recognize and respond to foreign RNA, which could lead to better ways to fight antibiotic resistance and create new technologies that might help patients in the future.
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Exploring the different structures of amyloid aggregates in Alzheimer's disease
This study is looking at how certain proteins can misfold and clump together in ways that are connected to Alzheimer's and other diseases, and it hopes to help patients by uncovering how these clumps affect the progression of their conditions.
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Testing a mindfulness app to help future teachers manage stress
This study is testing a mobile app that teaches mindfulness techniques to university students training to become teachers, helping them manage stress and anxiety during their studies.
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Using cold to trigger local anesthesia for pain relief
This study is exploring a new way to manage pain using a special anesthetic that works better when it's cooled down, so patients can get relief from pain safely and effectively whenever they need it.
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Improving safety for tow truck operators on the road
This study is looking at how to make tow truck operators safer while they work on the roadside by understanding what causes accidents and injuries, so we can come up with better ways to protect them.
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Investigating a protein's role in Salla disease and its symptoms
This study is looking at how changes in the SLC17A5 gene affect the development of Salla disease, which can cause problems like seizures and trouble with movement, using tiny worms to help understand the disease better.
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How bacterial meningitis affects blood vessels in the brain
This study is looking at how bacterial meningitis affects the protective barrier around the brain, using special human cell models to see how bacteria can break through and cause problems, with the hope of finding new ways to help people who are dealing with this serious illness.
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Improving newborn screening methods for genetic disorders
This study is working to improve the way newborns are tested for genetic disorders like cystic fibrosis, especially for babies in underserved areas, so that all parents can trust their little ones are getting the right tests and care right from the start.
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Creating specialized micelles to enhance light-based cancer treatment for breast cancer
This study is testing a new way to improve light-based treatments for breast cancer by using special tiny carriers that help activate a new medicine with light, aiming to make the treatment more effective and easier on your body, all while allowing you to receive care in a comfortable outpatient setting.
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Mindfulness program for college students with ADHD
This study is looking at how a special 8-week mindfulness program can help first-year college students with ADHD feel better by managing their symptoms and reducing anxiety and depression, and it’s designed just for them!
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