Creating specialized polymers to improve drug delivery through the gut-blood barrier
Official title: Polyesters with controlled topologies for probing transcytosis at the gut-blood barrier
Funded at University of Alabama in Tuscaloosa · NIH-10925300 · Data updated 2026-11-12
This study is exploring new tiny particles made from special materials that can help deliver medications more effectively when taken by mouth, aiming to improve how these treatments work in the body for people who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $326,110 |
| NIH project number | 5R01GM146097-02 |
| Project ID | NIH-10925300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who require medications that are typically difficult to deliver effectively through oral routes.
✕Less likely to help
Patients who do not take medications orally or have conditions that require alternative delivery methods may not benefit from this research.
What this research studies
This research focuses on developing new types of polymer nanoparticles that can effectively deliver medications when taken orally. It addresses two main challenges: the need for versatile polymer structures that can customize drug delivery and the lack of tools to predict how these drug-laden nanoparticles behave in the body. By conducting various laboratory and animal tests, the researchers aim to gain insights into how these polymers are absorbed and processed in the body. The ultimate goal is to create a mathematical model that can help translate these findings from preclinical studies to clinical applications.
Why it matters
Potential benefit: If successful, this research could lead to more effective oral drug delivery systems, improving treatment options for patients.
How similar studies have gone: Previous research has shown promise in using polymer nanoparticles for drug delivery, indicating that this approach has potential for success.
Where this research is happening
-
University of Alabama in Tuscaloosa
Tuscaloosa, United States Active
Researchers
- Principal investigator: Majeti, Ravikumar N — University of Alabama in Tuscaloosa
- Study coordinator: Majeti, Ravikumar N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.