Improving oral drug delivery using polymer nanoparticles
Official title: Proposal for Administrative supplement to Purchase NanoSight Pro
Funded at University of Alabama in Tuscaloosa · NIH-11093284 · Data updated 2026-11-12
This study is exploring new ways to help medicines work better when taken by mouth, using tiny particles made from special materials that can help drugs get into your body more effectively, and it's designed for anyone interested in improving how medications are delivered.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $171,763 |
| NIH project number | 3R01GM146097-02S1 |
| Project ID | NIH-11093284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who need medications that are currently difficult to deliver effectively through oral routes.
✕Less likely to help
Patients who do not require oral medications or those with conditions that necessitate alternative delivery methods may not benefit from this research.
What this research studies
This research focuses on enhancing the delivery of pharmaceutical drugs through the use of polymer nanoparticles that can be administered orally. The project aims to address two main challenges: the need for versatile polymer structures for customized drug delivery and the development of predictive tools for understanding how these nanoparticles behave in the body. By synthesizing specialized polyesters and creating mathematical models, the research will investigate how these nanoparticles can effectively cross barriers in the body, such as the gut-blood barrier. This work involves a combination of laboratory experiments and computational modeling to provide insights into how drugs are absorbed, distributed, metabolized, and eliminated.
Why it matters
Potential benefit: If successful, this research could lead to more effective oral drug delivery systems, improving treatment outcomes for patients requiring medication.
How similar studies have gone: While the use of polymer nanoparticles for drug delivery is a growing field, this specific approach combining advanced polymer synthesis with predictive modeling is relatively novel.
Where this research is happening
-
University of Alabama in Tuscaloosa
Tuscaloosa, United States Active
Researchers
- Principal investigator: Majeti, Ravikumar N — University of Alabama in Tuscaloosa
- Study coordinator: Majeti, Ravikumar N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.