Exploring the different structures of amyloid aggregates in Alzheimer's disease
Official title: Investigating structural heterogeneities in amyloid aggregates with multiscale infrared spectroscopic imaging
Funded at University of Alabama in Tuscaloosa · NIH-10878949 · Data updated 2026-11-12
This study is looking at how certain proteins can misfold and clump together in ways that are connected to Alzheimer's and other diseases, and it hopes to help patients by uncovering how these clumps affect the progression of their conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project start | September 15, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $359,659 |
| NIH project number | 5R35GM138162-05 |
| Project ID | NIH-10878949 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without amyloid-related pathologies may not benefit from this research.
What this research studies
This research investigates how specific proteins misfold and aggregate into amyloid deposits, which are linked to Alzheimer's disease and other neurodegenerative disorders. By using advanced infrared spectroscopic imaging techniques, the study aims to identify the various structural forms of these amyloid aggregates and their relationship to disease progression. The research will initially focus on Alzheimer's disease but may extend to other conditions like Parkinson's disease and breast cancer. Patients may benefit from a better understanding of how these aggregates contribute to disease severity and progression.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for Alzheimer's disease and related disorders.
How similar studies have gone: Previous research has shown promising results in understanding amyloid aggregates in neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Alabama in Tuscaloosa
Tuscaloosa, United States Active
Researchers
- Principal investigator: Ghosh, Ayanjeet — University of Alabama in Tuscaloosa
- Study coordinator: Ghosh, Ayanjeet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.