Sponsor or institution
Clinical trials and research at Trustees of Indiana University
As of November 12, 2026, Find a Trial lists 223 NIH-funded research projects at this institution, with $100.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 223NIH research projects
NIH-funded research (newest 40 of 223)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Cloud-based tools to find genes linked to congenital heart defects in kids
Aimed at building and using cloud-based biostatistical tools to identify genes related to congenital heart defects in children using large pediatric datasets.
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Understanding how extreme weather and disasters affect women’s health in sub-Saharan Africa
A data-driven project uses mobile phone data and AI to study how shocks like weather disasters and conflicts impact women’s health in sub-Saharan Africa.
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Cash transfers in South Africa to reduce dementia risk in later life
This project tests whether government cash transfers in rural South Africa help protect people’s thinking and memory as they age.
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Functional lipids shape memory of membrane proteins like Kir channels and GPCRs
A research project will study how cholesterol and other lipids in cell membranes affect how membrane proteins work, using advanced NMR and computer simulations, with results that could inform understanding of how these proteins contribute to disease.
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Understanding HIV immune escape to guide vaccines and cures
Researchers are building a robust computational method to identify universal HIV escape patterns across diverse viral strains to help design better vaccines and therapies for people living with HIV.
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Personalized brain stimulation to boost memory in aging and dementia
This project uses personalized, adaptive brain stimulation to try to improve memory and thinking in older adults with mild cognitive impairment or early dementia.
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AI-powered MegaPixel tool for rapid bacterial ID in sepsis care
A new AI-enabled platform aims to identify bloodstream bacteria quickly from patient samples, helping doctors choose the right treatment within hours.
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Toxicity of Benzalkonium Chloride on the Front of the Eye
This project looks at how long-term exposure to a common eye preservative, benzalkonium chloride (BAK), can harm the surface of the eye and potentially lead to eye surface disease.
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High-resolution maps of dengue mosquitoes and where they live
This grant aims to map where Aedes mosquitoes that spread dengue live and how they use their habitats, to help protect communities in the Americas and parts of the US.
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iRISE: Machine learning to predict when people in recovery might disengage from online recovery communities
A new AI-based project aims to spot signs that someone in a recovery community could drift away, so help can be offered to keep them on track.
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New ways to build complex, 3-D drug-like molecules using single-electron chemistry
Researchers are testing radical-based, base-metal catalysts to rapidly build 3-D medicinal chemistry scaffolds with fluorine and other useful groups, aiming to expand the diversity of drug candidates.
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CB2 makes skin itch relief more possible: targeting itch pathways in humans
A study explores how activating the CB2 receptor in skin cells and immune cells could reduce chronic itch in conditions like dermatitis, with results aimed at safer, peripherally focused treatments.
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Care quality and safety for people with dementia during home health agency ownership changes
A study will look at how changes in who owns home health agencies affect care and outcomes for people living with dementia who rely on home health services.
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Prevention of Maternal Depression Across 25 Years in Diverse Contexts with a Parenting Support Program
A long-term study in low-income families will explore how mothers’ depression changes over 25 years and whether a family-focused parenting program can help reduce depressive symptoms.
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Behavioral, circuit, and molecular mechanisms behind UCS deflation to reduce fear relapse
A study at Indiana University will explore a new way to reduce fear that may help with anxiety disorders by weakening fear memories more effectively than standard extinction.
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RNA location and local protein-making in brain circuits tied to opioid use disorder
A study exploring how RNA localization and local protein production in brain cells contribute to lasting brain changes and relapse risk in people with opioid use disorder.
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Structural basis of HIV RNA control to block virus growth
A scientist team is studying how HIV uses a key RNA element and a viral protein to make more virus, with the aim of finding new ways to stop replication.
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Understanding how heat and work exposures affect kidney health in outdoor workers
This project looks at why outdoor workers are at higher risk for kidney problems due to heat exposure and related stress on the kidneys.
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Understanding how teens’ social media words relate to mood over time
A long-term study of teens and young adults will look at how the language they use on their phones relates to anxiety and other internalizing symptoms, using real-time surveys and phone data.
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Target-Specific Dyes with Long-Lived Fluorescence for Biological Insight
Researchers are developing special fluorescent dyes that glow longer and change with cellular signals, helping doctors and scientists understand how cells communicate.
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Intelligent droplet platform to automate liquid handling in biomedical research
A new AI-powered droplet platform would automate and monitor tiny liquid handling in biology and medicine, potentially speeding up experiments and improving reliability.
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Acute and Long-Term Brain Effects of Sexual Choking in Young Adults with Acquired Brain Injury
This study follows young adults, especially women, to understand how being choked during sex might affect brain health and mental well-being over time.
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Understanding how cancer cells interact to shape tumors using computer simulations and multi-omics data
A patient-facing look at a project that uses advanced single-cell and spatial data to model how cancer cells talk to each other and respond to treatments.
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Understanding how HIV uses the nuclear pore to affect its infection and activation in immune cells
This NIH grant explores how HIV-1 interacts with the cell’s nuclear gateway to change how it enters the nucleus and how its genes are expressed, with the goal of informing future treatments.
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Understanding how the retina adapts after gene therapy to restore vision
This grant studies how the retina adapts after gene therapy in people with inherited retinal conditions to help improve and sustain vision.
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How bacteria switch to a surface-attached age and how small molecules control it
Scientists are studying how certain bacteria decide to stick to surfaces, form biofilms, and become tougher to treat, with a focus on tiny chemical signals called pterins that influence this process.
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Predicting how environmental chemicals affect the body with advanced data methods
Researchers aim to predict which body targets and tissues are affected by new environmental chemicals using advanced data-completion algorithms.
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ADHD medications and substance-related health risks in youth
This grant looks at how ADHD medicines affect substance use problems and related health issues in young people with ADHD.
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High-Resolution Charge Detection Mass Spectrometry for Better Understanding Large Molecules
A new CD-MS method aims to measure accurate mass distributions of complex, large molecules using single ions to help scientists better analyze diverse samples.
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Cash transfers in South Africa linked to later-life memory and dementia risk
A researchers’ team is testing whether government cash transfers in rural South Africa can help protect older adults from memory decline and dementia.
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Improving genetic resources for researchers using fruit flies
A project that keeps and shares a large collection of fruit fly strains so scientists can study biology and human health more effectively.
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Curation and Informatics for Drosophila Stock Center data and resources
A grant to improve how researchers manage, curate, and share Drosophila stock data and living lines that are widely used in human health research.
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Drosophila Stock Center: Acquire Maintain and Share Fly Strains
A national resource is collecting, keeping, and sharing living fruit fly strains to support biomedical research and human health.
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Bloomington Drosophila Stock Center at Indiana University
A long-running NIH grant preserves and shares fruit fly lines that help scientists study human biology and disease.
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Quorum sensing in bacteria: how cell communication shapes virulence
A scientist at Indiana University is studying how bacteria talk to each other and how this communication controls dangerous behaviors in bacteria like virulence and biofilm formation.
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How social connections change DNA and affect aging-related diseases
This project looks at whether people’s everyday social contact patterns are linked to DNA changes that relate to aging and diseases like Alzheimer’s.
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Programmable HBV Capsid Particles for Targeted Cargo Delivery
A project to engineer hepatitis B virus capsids into customizable delivery vehicles that can carry or display cargo for antiviral and therapeutic applications.
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Elucidating chemical signals that shape multicellularity and infectious disease transmission
Researchers are studying how chemicals used for cell communication in microbes influence the way diseases spread and how multicellular organisms develop.
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Understanding how everyday stress in urban and rural settings may affect dementia risk
This project follows people with mild cognitive impairment to see how daily stress and environment influence dementia-related changes, using a mobile app and smartwatch over two weeks.
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Circadian Clock Networks and Timekeeping in the Brain
Researchers study how the brain’s clock network keeps daily rhythms and how environmental cues like light help or hinder them, using fruit flies to uncover ideas that could help people with circadian-related health issues.
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