Understanding how cancer cells interact to shape tumors using computer simulations and multi-omics data
Official title: Informing mechanistic rules of agent-based models with single-cell multi-omics
Funded at Trustees of Indiana University · NIH-11413782 · Data updated 2026-11-12
A patient-facing look at a project that uses advanced single-cell and spatial data to model how cancer cells talk to each other and respond to treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $673,053 |
| NIH project number | 5U24CA284156-03 |
| Project ID | NIH-11413782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with cancer whose tumor tissues can be analyzed with single-cell and spatial multi-omics methods.
✕Less likely to help
Patients whose tumors cannot be studied with these specific omics techniques may not benefit directly.
What this research studies
Researchers will combine single-cell and spatial multi-omics data with an agent-based computer model to simulate how cancer cells and their surroundings interact over time. By linking real genomic data to virtual experiments, they aim to uncover rules that govern tumor behavior. The goal is to better predict how tumors evolve and respond to therapies in individual patients. This work builds on existing software to bridge biology data and dynamic tissue simulations.
Why it matters
Potential benefit: If successful, this project could improve our ability to predict tumor behavior and responses to treatment for individual patients.
How similar studies have gone: Previous studies using multi-omics data and simulations have shown promise in understanding tumor dynamics, suggesting potential for impactful insights here.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Macklin, Paul T — Trustees of Indiana University
- Study coordinator: Macklin, Paul T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.