High-Resolution Charge Detection Mass Spectrometry for Better Understanding Large Molecules
Official title: Advancing High-Resolution Charge Detection-Mass Spectrometry
Funded at Trustees of Indiana University · NIH-11393852 · Data updated 2026-11-12
A new CD-MS method aims to measure accurate mass distributions of complex, large molecules using single ions to help scientists better analyze diverse samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $274,622 |
| NIH project number | 5R01GM155650-03 |
| Project ID | NIH-11393852 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient recruitment; this is a technology development grant in a laboratory setting.
✕Less likely to help
No direct patient involvement in this stage of development.
What this research studies
This grant focuses on improving a specialized mass spectrometry technique called charge detection mass spectrometry (CD-MS) to measure the mass of heterogeneous and high-mass samples. Researchers will work on increasing the technique's resolving power and speeding up measurements by refining the electrostatic linear ion trap and its detection cylinder. The work combines computer simulations and experimental adjustments to align components more precisely and achieve much higher mass accuracy. Outcomes could enable clearer analysis of big biomolecules, virus-related particles, and other complex samples relevant to health and disease.
Why it matters
Potential benefit: If successful, patients could benefit from more accurate analysis of complex biological materials that inform diagnostics and therapeutic development.
How similar studies have gone: Previous CD-MS work has demonstrated progress, with ongoing improvements in resolution and speed.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Jarrold, Martin F — Trustees of Indiana University
- Study coordinator: Jarrold, Martin F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.