Predicting how environmental chemicals affect the body with advanced data methods
Official title: Improving chemical exposome target prediction by application of Coupled Matrix/Tensor-Matrix/Tensor Completion algorithms
Funded at Trustees of Indiana University · NIH-11394886 · Data updated 2026-11-12
Researchers aim to predict which body targets and tissues are affected by new environmental chemicals using advanced data-completion algorithms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00ES034429-04 |
| Project ID | NIH-11394886 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly recruiting patients; results could influence future human studies by identifying potential targets and tissues of concern.
✕Less likely to help
Direct patient participation is not required for this project.
What this research studies
This project uses complex mathematical methods to integrate existing chemical and biological data and forecast where and how new chemicals may act in the human body. The team will test and refine these methods on exposure datasets, compare them with other approaches, and create a web portal so scientists can explore predicted targets. A mentored phase supports training and career development for the investigator while building a path toward translational science. Experimental validations are planned to confirm the predictions in real-world scenarios.
Why it matters
Potential benefit: If successful, the work could speed up safety assessments and help prioritize which chemicals deserve further study.
How similar studies have gone: This approach is the first to apply matrix/tensor completion to exposure-target prediction, with validation planned to support its novelty.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Wang, Kai — Trustees of Indiana University
- Study coordinator: Wang, Kai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.