Structural basis of HIV RNA control to block virus growth
Official title: Structural Basis of HIV-1 Rev Response Element and Rev Assembly
Funded at Trustees of Indiana University · NIH-11419982 · Data updated 2026-11-12
A scientist team is studying how HIV uses a key RNA element and a viral protein to make more virus, with the aim of finding new ways to stop replication.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | June 24, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,595,769 |
| NIH project number | 1R01AI200842-01 |
| Project ID | NIH-11419982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient enrollment in this grant since it is a basic science study.
✕Less likely to help
No immediate patient care changes; potential benefits would come from future therapeutic development.
What this research studies
This project focuses on the HIV Rev–RRE interaction, a critical step in viral RNA export and replication. Researchers will determine the full-length RRE structure and how Rev proteins assemble with it, using advanced structural biology methods. The goal is to uncover new targets for drugs that could stop HIV from producing essential viral components. The work builds on prior findings and aims to reveal actionable insights for future therapies that can complement or bypass current antiretroviral drugs.
Why it matters
Potential benefit: If successful, the findings could lead to new drug targets that hinder HIV replication and help people living with HIV achieve better long-term control of the virus.
How similar studies have gone: Previous structural work on parts of the RRE has guided this deeper investigation into the full-length RNA and Rev complex.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Choi, Kyung H — Trustees of Indiana University
- Study coordinator: Choi, Kyung H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.