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Clinical trials and research at The Methodist Hospital Research Institute

• 48Clinical trials
• 2Countries

Newest trials

All recruiting trials (48)

• Nasal Dilator Therapy for Patulous Eustachian Tube

  This study tests whether wearing a nasal dilator helps reduce symptoms in adults with patulous Eustachian tube dysfunction.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT07796139

• IL-2 plus semaglutide in Alzheimer's disease

  This study tests a combination of IL-2 and semaglutide to see if it can help people with Alzheimer's disease.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT07651319

• VR-based cognitive games to help prevent delirium after big surgery

  A VR-based cognitive stimulation game is being tested to see if it can help prevent delirium in adults 65 and older after major surgery.

  Recruiting at 2 sites The Methodist Hospital Research Institute · Houston, Texas and 1 other locations · NCT07641153

• Anti-CMV treatment for breast cancer that has spread to the brain with CMV infection

  This trial tests whether adding the anti-CMV drug valganciclovir to standard care helps adults with breast cancer that has spread to the brain who have detectable CMV.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT07383649

• Adding spiritual care or psychotherapy to palliative care for people with advanced cancer

  This trial will see if adding chaplain-led spiritual care or psychotherapy with meditation to standard palliative care (and chemotherapy when recommended) helps people with advanced, non-curative cancer live longer.

  Recruiting Phase 3 The Methodist Hospital Research Institute · Houston, Texas · NCT07290491

• VoiceLove recorded-family-voice therapy for ICU delirium

  This study will try playing recorded messages from a loved one at the bedside to see if adults in the surgical ICU at risk for delirium can tolerate 20–25 minute sessions and find them acceptable.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT07218484

• High-dose brachytherapy before robotic radical prostatectomy for high-risk prostate cancer

  This trial will test whether a single high-dose (15 Gy) brachytherapy treatment given 4–8 weeks before robotic prostate removal helps people with newly diagnosed, non-metastatic high-risk prostate cancer.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT07182279

• Nal-IRI plus 5-FU/LV and oxaliplatin as first-line therapy for advanced small intestine and appendix cancers

  This trial tests whether the NALIRIFOX combination can be given as the first treatment to see if it is safe and helpful for adults with advanced small intestine or appendix cancers.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas and 1 other locations · NCT07060014

• Efficacy of HMAs vs Intensive Chemotherapy in AML Guided by 5hmC MRD

  This trial tests whether a blood 5hmC biomarker can guide choosing between hypomethylating agents or intensive chemotherapy for adults with newly diagnosed AML.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT07060001

• Comprehensive pre-surgery conditioning, with or without planned preoperative cancer therapy, before major abdominal or pelvic cancer operations.

  This trial will test whether a comprehensive prehabilitation program, given alone or with planned neoadjuvant therapy, helps pre-frail or frail adults with pancreatic, ovarian, kidney, or bladder cancer better tolerate major cancer surgery.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT07050771

• Stem cells to help erectile function after prostate surgery

  This phase 1/2 study tests whether injected stem cells can help men recover erectile function after radical prostatectomy for localized prostate cancer, compared to placebo.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT07048314

• 5‑Fluorouracil–based chemotherapy plus fruquintinib for advanced or metastatic colorectal cancer

  This phase II test will combine 5‑FU–based chemotherapy with the oral drug fruquintinib as a first-line treatment for adults with locally advanced unresectable or metastatic colorectal cancer.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT07042685

• High-dose dexamethasone to relieve ureteral stent symptoms after kidney stone procedure

  In people undergoing ureteroscopy with a ureteral stent, the study tests whether a 20 mg dose of dexamethasone helps reduce urinary symptoms and pain more than a 4 mg dose.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT06930690

• 5-FU and leucovorin plus regorafenib versus trifluridine‑tipiracil with bevacizumab for third-line metastatic colorectal cancer

  This trial tests whether combining 5-FU and leucovorin with regorafenib works as well as trifluridine‑tipiracil plus bevacizumab for people with metastatic colorectal cancer who have already had two prior lines of treatment.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT06887218

• Prehabilitation program for kidney transplant candidates

  This study is testing if using wearable sensors during exercise can help kidney transplant candidates get stronger and better prepared for their surgery.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06886256

• Combining Hydroxytyrosol with 5-Fluorouracil for Advanced Colorectal Cancer

  This study is testing if adding Hydroxytyrosol to standard chemotherapy can help people with advanced colorectal cancer feel better and fight their disease.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas · NCT06833866

• Enhancing COVID-19 vaccine response in older adults with Thymalfasin

  This study is testing if a medication called Thymalfasin can help older adults respond better to their COVID-19 booster shots.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas · NCT06821100

• ACL reconstruction using your own knee fat–derived stem cells

  This will try a single injection of your own mesenchymal stem cells taken from the fat under the kneecap to see if it is safe and helps recovery after ACL reconstruction with a patellar tendon autograft.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas · NCT06798623

• MRI-guided management of occlusive peripheral arterial disease

  This study is testing how MRI scans can help doctors understand plaque in the arteries of people with peripheral arterial disease and see if certain devices can make treatments safer.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06782100

• Non-invasive vagus nerve stimulation for stroke recovery

  This study is testing if a new non-invasive treatment using vagus nerve stimulation can help stroke survivors with arm weakness recover better when combined with occupational therapy.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06761404

• Improving hospital environments to reduce delirium in older adults

  This study is testing if improving the hospital environment to help older adults sleep better can reduce the chances of them developing delirium while they're hospitalized.

  Recruiting at 5 sites The Methodist Hospital Research Institute · Baytown, Texas and 4 other locations · NCT06736951

• Bone stimulator treatment for spondylolysis in athletes

  This project will test whether adding a bone stimulator to usual care helps athletes aged 16 to 40 with symptomatic spondylolysis reduce pain, improve function, heal the bone, and return to sport sooner.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06666608

• Effects of Blood Flow Restriction Training on Elbow Ligament Thickness

  This study is testing if low-intensity exercises with blood flow restriction can make the elbow ligament thicker and stronger in healthy volunteers.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06664827

• Comparing two methods of antibiotic delivery during knee surgery

  This study is testing whether giving antibiotics directly into the bone during knee surgery works better than the usual method of giving them through an IV to help reduce complications after surgery.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT06640491

• Using honokiol to prevent lung cancer recurrence before surgery

  This study is testing if taking honokiol, a dietary supplement, can safely help prevent lung cancer from coming back in patients with early-stage non-small cell lung cancer before their surgery.

  Recruiting Phase 1 The Methodist Hospital Research Institute · Houston, Texas · NCT06566443

• Combination therapy using ATRA and Carfilzomib for Multiple Myeloma patients

  This study is testing if a new combination of two drugs, ATRA and Carfilzomib, can help people with tough-to-treat Multiple Myeloma feel better when other treatments haven't worked.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT06536413

• Using intraosseous morphine to manage pain during ACL reconstruction

  This study tests if giving morphine directly into the bone can help reduce pain and the need for other pain medications in young adults having ACL surgery.

  Recruiting Phase 4 The Methodist Hospital Research Institute · Houston, Texas · NCT06511232

• Comparing two ways to give antibiotics during ankle surgery

  This study is testing whether giving antibiotics directly into the bone or through an IV during ankle surgery works equally well to prevent infections after the operation.

  Recruiting Phase 4 The Methodist Hospital Research Institute · Houston, Texas · NCT06384651

• Using CBD to manage pain after shoulder surgery

  This study is testing if a CBD medication can help people manage pain better after shoulder surgery compared to a placebo.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT06381791

• Endoscopic Sleeve Gastroplasty for treating obesity

  This study is testing if a new procedure called endoscopic sleeve gastroplasty can help people with obesity lose weight when diet and exercise haven't worked for them.

  Recruiting at 2 sites The Methodist Hospital Research Institute · Houston, Texas and 1 other locations · NCT06339320

• Protein supplementation after ACL surgery

  This study is testing if adding protein supplements after ACL surgery can help young patients keep their muscle size and strength as they recover.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06311058

• Home telerehabilitation therapy for patients with vascular dementia

  This study is testing whether home telerehabilitation therapy can help stroke patients with and without vascular dementia improve their arm strength and reduce the stress on their caregivers.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06289569

• Personalized brain stimulation for stroke recovery

  This study is testing if a personalized brain stimulation treatment can help people who have had a stroke recover better and improve movement in their affected arm during therapy.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06286800

• Using blood flow restriction therapy after Achilles tendon surgery

  This study tests if adding blood flow restriction therapy to regular physical therapy helps people recover better after Achilles tendon surgery.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06254794

• Using epidural stimulation to improve rehabilitation outcomes for cervical spinal cord injuries

  This study is testing if a new treatment using epidural stimulation along with arm exercises can help people with cervical spinal cord injuries improve their arm function.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06225245

• Using non-invasive spinal stimulation to improve recovery after spinal cord injury

  This study is testing two non-invasive spinal stimulation methods to see if they can help people with spinal cord injuries recover their ability to stand and move better.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06213012

• Modulating brain regions to treat bladder issues in multiple sclerosis

  This study is testing whether a new brain stimulation technique can help women with multiple sclerosis who have bladder problems feel better by focusing on the brain instead of just the bladder.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06072703

• Combining alpelisib with chemotherapy for HER2 negative metaplastic breast cancer

  This study is testing whether combining a new drug called alpelisib with chemotherapy can help people with a rare and tough type of breast cancer feel better and improve their treatment results.

  Recruiting at 3 sites Phase 2 The Methodist Hospital Research Institute · Bethesda, Maryland and 2 other locations · NCT05660083

• Imaging brain inflammation in Alzheimer's disease

  This study is testing a new imaging technique to see if it can help us understand brain inflammation in people with Alzheimer's disease compared to healthy individuals.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT05582200

• Using venous ethanol to improve treatment for ventricular tachycardia

  This study is testing if adding venous ethanol to standard heart treatment can help people with ventricular tachycardia feel better and reduce their chances of having problems in the future.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT05511246

• Combination treatment for advanced breast cancer

  This study is testing if a new combination of two drugs can help women with advanced breast cancer who haven't responded to previous treatments.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT05305924

• Clazakizumab vs placebo for COVID-19 with lung involvement

  This study tests whether clazakizumab can help adults with COVID-19 who have lung involvement, by comparing it to a placebo.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT04494724

• Using cardiac MRI to improve understanding and management of heart diseases

  This study is testing how cardiac MRI can help doctors better understand and manage heart diseases in patients with known or suspected cardiovascular conditions.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT04281823

• Using Ocrelizumab to treat psychosis caused by autoimmunity

  This study tests if the medication Ocrelizumab can help young adults with schizo-affective psychosis and schizophrenia caused by autoimmune issues feel better.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03971487

• Gene therapy combined with radiation and chemotherapy for newly diagnosed brain tumors

  This study is testing a new gene therapy combined with radiation and chemotherapy to see if it can help people who have just been diagnosed with aggressive brain tumors like glioblastoma or anaplastic astrocytoma.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03603405

• Gene therapy and chemotherapy for recurrent glioblastoma

  This study is testing a new treatment combining gene therapy, a medication, and radiation with chemotherapy to see if it helps people with recurrent glioblastoma or anaplastic astrocytoma who haven't responded to other treatments.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT03596086

• Gene therapy plus hormone therapy, radiotherapy, and surgery for high-risk prostate cancer

  This phase II trial tests HSV-tk gene therapy with valacyclovir alongside hormone therapy, brachytherapy, external beam radiotherapy, and prostatectomy in men with untreated high-risk prostate cancer.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT03541928

• Registry for patients with spinal cord injuries in North America

  This study is collecting information from people who have had their first spinal cord injury to see how their treatment and recovery progress over the first year.

  Recruiting at 8 sites The Methodist Hospital Research Institute · Miami, Florida and 13 other locations · NCT00178724

Quick answers

How many clinical trials run by The Methodist Hospital Research Institute are recruiting right now?

48, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (48 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1/2: 10, Phase 1: 5, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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