Sponsor or institution
Clinical trials and research at Texas Tech University Health Scis Center
As of November 12, 2026, Find a Trial lists 61 NIH-funded research projects at this institution, with $35.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 61NIH research projects
NIH-funded research (newest 40 of 61)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Glycan changes on brain blood vessels and their role in Alzheimer’s-related brain vascular disease
Researchers are studying how sugar molecules on brain blood vessel surfaces affect the buildup of amyloid and the development of cerebral amyloid angiopathy in people with Alzheimer’s disease.
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Cholesterol in Liposomal Cancer Drugs and Safer Formulations
A researcher at Texas Tech University Health Sciences Center is studying how cholesterol in liposome-based cancer drugs interacts with the body’s immune system to improve or worsen tumor growth, with the goal of making safer, more effective treatments.
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Protein-Based Inheritance in Mammals
A research project explores how environmental exposures in fathers might affect the health and traits of their children and grandchildren.
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Endogenous retroviruses and alcohol use disorder
A new study explores how ancient viral elements in our DNA might be activated by alcohol and contribute to alcohol use disorder, potentially guiding new treatments.
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Understanding how ER quality control affects protein movement and stress signals in diabetes-related cells
Aims to understand how the cell’s quality-control system in the endoplasmic reticulum affects protein handling and stress responses in adults with type 2 diabetes.
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Blocking FOXO4 to protect the brain after stroke
Researchers aim to find out if blocking a protein called FOXO4 can protect the brain and reduce Alzheimer-like damage after an ischemic stroke.
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Boosting vitamin A and gene activity in the brain's memory center
This research aims to see whether vitamin A supplements together with drugs that boost gene activity can restore key memory-related genes in older adults and people with Alzheimer's.
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Understanding how cation-coupled transporters work and how they relate to cancer
This grant studies how certain transporter proteins move molecules in and out of cells and how this affects cancer and other diseases, with a focus on mammalian transporters like SLC6A14.
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Blocking a key amino acid transporter (SLC6A14) to fight pancreatic cancer
This research tests whether stopping a protein that brings amino acids into pancreatic cancer cells can slow tumor growth for people with pancreatic ductal adenocarcinoma.
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Blocking EphB1/2 to treat peripheral nerve (neuropathic) pain
This work is developing new non-opioid drugs that target EphB1/2 signaling to reduce peripheral neuropathic pain for people with nerve injury or chronic nerve pain.
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Remote speech therapy for children with repaired cleft palate
This project sees if online speech therapy helps young children who had cleft palate repairs improve how they make and hear speech sounds.
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How Mucor fungi use calcineurin and related proteins to cause infection
Looking for fungal-only weak spots in Mucor infections that could lead to safer antifungal drugs for people with weakened immune systems.
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Targeting Shared Vulnerabilities in ALT Cancers to Improve Therapy
This NIH grant aims to understand and target weaknesses in cancers that use ALT to maintain telomeres, with the goal of making tumors more responsive to treatment.
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Retinoic acid's role in protecting memory-related brain cells in Alzheimer's
This work looks at whether restoring a vitamin A–related molecule and its genes can protect memory-center brain cells and slow early Alzheimer's changes.
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How the amygdala may keep neuropathic pain going
This work tests whether immune signaling between neurons and glial cells in the amygdala keeps neuropathic pain and its emotional effects going and whether blocking those signals could relieve chronic pain.
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Project FRONTIER: Understanding Alzheimer’s risk and protection in rural vs urban seniors
A NIH grant-funded project aims to understand how psychosocial and environmental factors affect brain health in older adults with Alzheimer’s disease and related dementias, comparing rural and urban communities to find ways to support better outcomes.
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New medicines to reduce brain injuries after non-fatal opioid overdoses
A patient-friendly look at a project aiming to create new medications to protect the brain after a non-fatal opioid overdose.
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Community Engagement Core for Rural Health in Texas
A Rural Health Community Engagement Core partners with local hospitals and clinics to improve access to care and health literacy by listening to communities and co-creating research with rural residents.
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Investigator Development Core for TTUHSC researchers in health disparities and rural health
A program to mentor early-career TTUHSC researchers and help them secure NIH K/R funding, with mentored pilot projects
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Translational Research and Rural Health Capacity Center
A Mayo-style patient-facing center that strengthens translational research and workforce in rural West Texas and surrounding areas to prevent and manage acute and chronic illnesses.
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Administrative Core for Translational Research and Rural Health at Texas Tech
A center-led effort to improve health in rural West Texas by coordinating translational research and community engagement to reduce chronic disease disparities.
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Center to speed up translating health research and improving rural Latino communities
A large center grant will build infrastructure to support translational science and rural health improvements for medically underserved Hispanic populations in West Texas and neighboring areas.
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How HIV proteins harm lung blood vessels
This research tests whether HIV proteins change lung blood-vessel cells and help cause pulmonary hypertension in people living with HIV.
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Developing new medications to treat alcohol use disorder
This study is looking at a new medication called BEM to see how it works in the body and if it’s safe to use with other drugs, all to help people who are dealing with alcohol use disorder.
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Telomere maintenance patterns as prognostic clues in high-risk neuroblastoma
This grant studies how the way cancer cells keep their chromosomes intact may predict outcomes for children with high-risk neuroblastoma and guide future treatments.
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Tests to identify how cancers keep their chromosome ends (telomeres) intact
This project is creating lab tests to tell whether a patient's cancer uses telomerase, the ALT pathway, or neither so doctors can better understand the tumor.
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How cholesterol in liposomal cancer medicines affects the tumor immune response
This research tests whether changing the cholesterol used in liposomal chemotherapy can stop those medicines from weakening the immune system against tumors.
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How changes in sex hormones affect long-term pain after surgery
This project looks at whether shifts in sex hormones help explain who gets lasting pain after surgery and how pain treatments work for them.
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Improving healthcare access in rural areas of Texas
This study is working to make healthcare easier to access for people living in rural Texas, so they can get better services and improve their health.
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Finding Hidden HIV in Lung Blood Vessels
This work aims to find where HIV hides in the body, specifically in the lung's blood vessels, to help us get closer to a cure.
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Investigating the role of FOXO4 in brain injury from ischemic stroke
This study is looking at how a gene called FOXO4 affects brain injuries from strokes, and it hopes to find ways to reduce damage and improve recovery for people who have had a stroke or are at risk for Alzheimer's disease.
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Improving speech for children with repaired cleft palate using telepractice
This study is looking at how well online speech therapy works for kids with repaired cleft palates, helping them improve their speech skills while making it easier for families to access therapy from home.
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Understanding how certain transport proteins work in cells
This study is looking at how certain transporters in our cells work, especially one called SLC6A14, to better understand their role in diseases like cancer, which could help find new ways to treat these conditions.
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Investigating how vitamin A can help improve memory and learning in aging and Alzheimer's disease.
This study is looking at how vitamin A and certain natural compounds might help improve memory and learning in older adults and people with Alzheimer's by boosting important brain functions that can be weakened by aging and stress.
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Investigating how P-glycoprotein interacts with various drugs
This study is looking at how certain medications interact with a protein in your body that helps remove harmful substances, which could lead to better and safer treatments for conditions like cancer, HIV/AIDS, and mental health issues.
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Targeting a specific amino acid transporter to treat pancreatic cancer
This study is looking at how blocking a specific protein called SLC6A14 can help slow down the growth of pancreatic cancer by cutting off the nutrients the cancer cells need, and it’s for anyone interested in new ways to treat this type of cancer.
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Exploring new antifungal treatments for Mucormycosis
This study is looking at how a protein called calcineurin helps certain fungi grow and cause a serious infection called mucormycosis, with the goal of finding new ways to treat this infection for patients who need better options.
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Finding new treatments for nerve pain using specific inhibitors
This study is looking for a new, safer way to help people with chronic nerve pain by testing a combination of existing antibiotics that might ease their symptoms without using opioids.
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Investigating how certain cancers maintain their telomeres and potential treatment targets.
This study is looking at certain types of cancer that grow in a different way than usual and aims to find special markers that could help us discover new treatments for patients with these cancers.
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Understanding how ion channels work and how they are influenced by cell membrane composition
This study is looking at how the makeup of cell membranes influences potassium channels, which are important for many body functions, to help find new treatments for conditions related to these channels.
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