Finding new treatments for nerve pain using specific inhibitors
Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic pain
This study is looking for a new, safer way to help people with chronic nerve pain by testing a combination of existing antibiotics that might ease their symptoms without using opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-11047339 on NIH RePORTER |
What this research studies
This research focuses on developing new, non-opioid therapies for managing chronic peripheral neuropathic pain, which is a significant public health issue due to the opioid crisis. The team will investigate the role of EphB1 tyrosine kinase inhibitors in reversing pain symptoms, using a combination of existing antibiotics that have shown promise in preliminary studies. By examining how these inhibitors affect pain pathways, the research aims to provide a safer alternative to traditional pain medications. Patients may benefit from a new treatment option that does not carry the risks associated with opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic peripheral neuropathic pain.
Not a fit: Patients with acute pain conditions or those not experiencing neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective, non-addictive treatments for chronic nerve pain.
How similar studies have performed: Previous studies have shown promise in using EphB1 inhibitors for pain management, indicating potential for success in this approach.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Ahmed, Mahmoud Salama — Texas Tech University Health Scis Center
- Study coordinator: Ahmed, Mahmoud Salama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.