Investigating how P-glycoprotein interacts with various drugs
Official title: Studies of P-glycoprotein drug interactions
Funded at Texas Tech University Health Scis Center · NIH-11074132 · Data updated 2026-11-12
This study is looking at how certain medications interact with a protein in your body that helps remove harmful substances, which could lead to better and safer treatments for conditions like cancer, HIV/AIDS, and mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | August 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $306,041 |
| NIH project number | 5R01GM141216-04 |
| Project ID | NIH-11074132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients receiving treatments for cancer, HIV/AIDS, or psychiatric disorders who may be affected by drug interactions.
✕Less likely to help
Patients not undergoing treatment for the conditions mentioned, or those not taking medications that interact with P-glycoprotein, may not benefit from this research.
What this research studies
This research focuses on P-glycoprotein, a crucial protein that helps detoxify cells by transporting harmful substances out. It plays a significant role in how drugs are absorbed and excreted in the body, particularly for treatments related to cancer, HIV/AIDS, and psychiatric conditions. The researchers will explore how different therapeutic drugs bind to specific sites on this protein, using advanced techniques to monitor these interactions. By understanding these mechanisms, the study aims to improve drug efficacy and safety.
Why it matters
Potential benefit: If successful, this research could lead to better drug therapies with fewer side effects for patients undergoing treatment for various serious conditions.
How similar studies have gone: Previous research has shown promising results in understanding drug interactions with P-glycoprotein, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Urbatsch, Ina L — Texas Tech University Health Scis Center
- Study coordinator: Urbatsch, Ina L
Related research
Other NIH-funded projects on the same topics.
-
Glycan changes on brain blood vessels and their role in Alzheimer’s-related brain vascular disease
Researchers are studying how sugar molecules on brain blood vessel surfaces affect the buildup of amyloid and the development of cerebral amyloid angiopathy in people with Alzheimer’s disease.
-
Cholesterol in Liposomal Cancer Drugs and Safer Formulations
A researcher at Texas Tech University Health Sciences Center is studying how cholesterol in liposome-based cancer drugs interacts with the body’s immune system to improve or worsen tumor growth, with the goal of making safer, more effective treatments.
-
Protein-Based Inheritance in Mammals
A research project explores how environmental exposures in fathers might affect the health and traits of their children and grandchildren.
-
Endogenous retroviruses and alcohol use disorder
A new study explores how ancient viral elements in our DNA might be activated by alcohol and contribute to alcohol use disorder, potentially guiding new treatments.
-
Understanding how ER quality control affects protein movement and stress signals in diabetes-related cells
Aims to understand how the cell’s quality-control system in the endoplasmic reticulum affects protein handling and stress responses in adults with type 2 diabetes.
-
Blocking FOXO4 to protect the brain after stroke
Researchers aim to find out if blocking a protein called FOXO4 can protect the brain and reduce Alzheimer-like damage after an ischemic stroke.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.