Investigating how P-glycoprotein interacts with various drugs
Studies of P-glycoprotein drug interactions
This study is looking at how certain medications interact with a protein in your body that helps remove harmful substances, which could lead to better and safer treatments for conditions like cancer, HIV/AIDS, and mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-11074132 on NIH RePORTER |
What this research studies
This research focuses on P-glycoprotein, a crucial protein that helps detoxify cells by transporting harmful substances out. It plays a significant role in how drugs are absorbed and excreted in the body, particularly for treatments related to cancer, HIV/AIDS, and psychiatric conditions. The researchers will explore how different therapeutic drugs bind to specific sites on this protein, using advanced techniques to monitor these interactions. By understanding these mechanisms, the study aims to improve drug efficacy and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients receiving treatments for cancer, HIV/AIDS, or psychiatric disorders who may be affected by drug interactions.
Not a fit: Patients not undergoing treatment for the conditions mentioned, or those not taking medications that interact with P-glycoprotein, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better drug therapies with fewer side effects for patients undergoing treatment for various serious conditions.
How similar studies have performed: Previous research has shown promising results in understanding drug interactions with P-glycoprotein, indicating that this approach has potential for significant advancements.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Urbatsch, Ina L — Texas Tech University Health Scis Center
- Study coordinator: Urbatsch, Ina L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.