Understanding how ion channels work and how they are influenced by cell membrane composition
Official title: A comprehensive thermodynamic and structural characterization of ion channel function and its regulation by the lipid bilayer composition
Funded at Texas Tech University Health Scis Center · NIH-11012306 · Data updated 2026-11-12
This study is looking at how the makeup of cell membranes influences potassium channels, which are important for many body functions, to help find new treatments for conditions related to these channels.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $344,250 |
| NIH project number | 5R35GM149523-03 |
| Project ID | NIH-11012306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cardiac arrhythmias or autoimmune conditions that may be linked to ion channel malfunctions.
✕Less likely to help
Patients with conditions unrelated to ion channel function or those not experiencing any ion channel-related disorders may not receive benefit from this research.
What this research studies
This research investigates the relationship between the structure and function of potassium channels, focusing on how the composition of cell membranes affects these channels. By examining the structural changes that occur during channel activation and ion permeation, the study aims to uncover the mechanisms that regulate potassium channel behavior. Advanced techniques, including atomic resolution imaging and calorimetry, will be employed to gain insights into ion binding and channel gating. The ultimate goal is to facilitate the development of new therapeutic drugs targeting these channels.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of novel treatments for conditions related to ion channel dysfunction, such as cardiac arrhythmias and autoimmune diseases.
How similar studies have gone: Previous research has shown success in understanding ion channel mechanisms, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Cuello, Luis Gonzalo — Texas Tech University Health Scis Center
- Study coordinator: Cuello, Luis Gonzalo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.