Investigating how certain cancers maintain their telomeres and potential treatment targets.
Targeting Shared Vulnerabilities in Alternate Telomere Lengthening (ALT) Cancers
['FUNDING_R01'] · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · NIH-11017846
This study is looking at certain types of cancer that grow in a different way than usual and aims to find special markers that could help us discover new treatments for patients with these cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS TECH UNIVERSITY HEALTH SCIS CENTER (nih funded) |
| Locations | 1 site (LUBBOCK, UNITED STATES) |
| Trial ID | NIH-11017846 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific cancers, particularly those that do not use the common telomerase method, maintain their telomeres through a process called Alternative Lengthening of Telomeres (ALT). By identifying unique biomarkers associated with ALT cancers, the study aims to uncover vulnerabilities in these cancer cells that could be targeted for treatment. The researchers will utilize a specialized assay to detect these biomarkers in various cancer types, which may lead to new therapeutic strategies for patients with ALT-positive tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ALT-positive cancers, which may include certain types of neuroblastoma and other malignancies.
Not a fit: Patients with cancers that do not exhibit ALT characteristics or those who do not have a diagnosis of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with ALT-positive cancers, improving their clinical outcomes.
How similar studies have performed: Previous research has shown promising results in targeting vulnerabilities in ALT cancers, indicating that this approach has potential for success.
Where this research is happening
LUBBOCK, UNITED STATES
- TEXAS TECH UNIVERSITY HEALTH SCIS CENTER — LUBBOCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REYNOLDS, CHARLES PATRICK — TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
- Study coordinator: REYNOLDS, CHARLES PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.