Investigating the role of FOXO4 in brain injury from ischemic stroke
Official title: FOXOs in ischemic stroke
Funded at Texas Tech University Health Scis Center · NIH-11145268 · Data updated 2026-11-12
This study is looking at how a gene called FOXO4 affects brain injuries from strokes, and it hopes to find ways to reduce damage and improve recovery for people who have had a stroke or are at risk for Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $382,500 |
| NIH project number | 5R01NS124846-04 |
| Project ID | NIH-11145268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have suffered an ischemic stroke or are at risk of developing Alzheimer's disease.
✕Less likely to help
Patients with non-ischemic stroke conditions or those who do not have any neurodegenerative diseases may not benefit from this research.
What this research studies
This research focuses on understanding how the FOXO4 gene influences brain injury caused by ischemic stroke. The study aims to explore the relationship between FOXO4 and neuroinflammation, mitochondrial dysfunction, and oxidative stress, which are critical factors in brain damage and the development of Alzheimer's disease-like symptoms. By using a mouse model, researchers will assess the effects of inhibiting FOXO4 to determine if it can reduce brain injury and improve recovery outcomes. The ultimate goal is to identify new therapeutic targets that could lead to better treatments for patients suffering from ischemic stroke and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for patients who have experienced an ischemic stroke.
How similar studies have gone: Previous research has shown promising results in targeting FOXO4 for neuroprotection, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Wang, Hongmin — Texas Tech University Health Scis Center
- Study coordinator: Wang, Hongmin
Related research
Other NIH-funded projects on the same topics.
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Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
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Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.