Investigating the role of FOXO4 in brain injury from ischemic stroke
FOXOs in ischemic stroke
This study is looking at how a gene called FOXO4 affects brain injuries from strokes, and it hopes to find ways to reduce damage and improve recovery for people who have had a stroke or are at risk for Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-11145268 on NIH RePORTER |
What this research studies
This research focuses on understanding how the FOXO4 gene influences brain injury caused by ischemic stroke. The study aims to explore the relationship between FOXO4 and neuroinflammation, mitochondrial dysfunction, and oxidative stress, which are critical factors in brain damage and the development of Alzheimer's disease-like symptoms. By using a mouse model, researchers will assess the effects of inhibiting FOXO4 to determine if it can reduce brain injury and improve recovery outcomes. The ultimate goal is to identify new therapeutic targets that could lead to better treatments for patients suffering from ischemic stroke and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have suffered an ischemic stroke or are at risk of developing Alzheimer's disease.
Not a fit: Patients with non-ischemic stroke conditions or those who do not have any neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for patients who have experienced an ischemic stroke.
How similar studies have performed: Previous research has shown promising results in targeting FOXO4 for neuroprotection, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Wang, Hongmin — Texas Tech University Health Scis Center
- Study coordinator: Wang, Hongmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.