Sponsor or institution
Clinical trials and research at Suny Downstate Medical Center
As of November 12, 2026, Find a Trial lists 71 NIH-funded research projects at this institution, with $58.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 71NIH research projects
NIH-funded research (newest 40 of 71)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Cross-talk between SARM1-driven axon damage and ferroptosis in brain hemorrhage
A study in people with brain bleeding (intracerebral hemorrhage) to understand how axons get damaged and how iron-related cell death contributes to disability.
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Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
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How SPTLC3 affects aging, diet, and heart disease risk
This study looks at how a particular enzyme SPTLC3 influences aging-related insulin resistance, fatty liver disease risk, and atherosclerosis, especially when eating a high-fat diet.
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Genetic links between PTSD and Alcohol Use Disorder in teens and adults
This grant studies how genetics and life experiences like childhood trauma shape the risk of PTSD and alcohol problems across adolescence into adulthood.
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Understanding how to build effective mentor networks for underrepresented researchers
A project to learn what kinds of mentoring networks help researchers from underrepresented groups succeed and stay in academia.
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Genomics Project: Understanding Alcoholism through genetics and life-span data
A big genetics study looks at how genes, brain biology, and environment influence alcohol use, remission, and relapse across people and their families.
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Brain function in alcohol use disorder across the lifespan
A large, long-running study looks at how genetics, brain biology, and life experiences influence alcohol use disorder from midlife into older age.
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Lifespan-focused genetics study of alcohol use disorders
A long-term study at SUNY Downstate explores how genes, biology, and life factors interact to influence alcohol use disorder across adulthood, especially after age 40.
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COGA Cell Repository for Alcoholism Genetics
A long-running study collects and stores genetic material and related data from families affected by alcohol use disorder to better understand its causes and course across life.
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Data Management Core for a long-term genetics of alcohol use disorder study
A data management core supports a large, multi-site study that looks at how genes, brain function, and environment influence alcohol use disorder across the lifespan.
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Understanding how genetics, brain biology, and life factors influence alcohol use across adulthood
A National Institutes of Health grant supports a long-term study of families to learn how genetics, brain biology, and environment interact to influence alcohol use, remission, and related health outcomes as people age.
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Genes, brains, and life: understanding alcoholism through family-based genetics
A large study of families explores how genes, brain biology, and life experiences interact to shape alcohol use, recovery, and relapse across the lifespan.
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Psychosis in Diverse Settings: Understanding Global Differences in Treatment and Genomics
Aims to understand how psychotic disorders differ in people from diverse global backgrounds and how genetic factors relate to treatment outcomes.
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Psychosis in people from diverse ancestries
This project compares how psychotic illnesses start, progress, and respond to treatment in adults of African and Caribbean ancestry in the US, Nigeria, and Trinidad and Tobago.
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Psychosis across diverse communities in Africa, the Caribbean, and the U.S.
Comparing how psychosis shows up and responds to treatment in people from the U.S., Africa, and the Caribbean while using whole genome sequencing to learn about genetic differences.
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Genetics of PTSD and Substance Use in Diverse Populations
This grant investigates how genes influence PTSD and substance use disorders in diverse groups to improve prevention and treatment.
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TRANSPORT II: Building diverse, community-partnered health disparities researchers
A funded program at SUNY Downstate to train a diverse group of scientists to study health disparities and work with Brooklyn communities to improve equity in health.
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Advancing Precision Psychiatry with Learning Health Systems
A research effort to use big data and AI to speed up accurate diagnosis and personalized treatment for people with mood and other affective disorders.
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How cells and viruses make proteins and clear faulty protein pieces
Researchers are learning how human and viral proteins are made and how cells remove faulty protein fragments, which may help people with viral infections or illnesses caused by broken protein production.
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MWCCS Brooklyn Clinical Research Site for HIV and aging health research
A long-running national study is renewing its Brooklyn site to better follow people living with HIV and other health conditions as they age, collecting health data to improve care.
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Repairing the eye's drainage support to lower pressure in steroid-related and open-angle glaucoma
This work tests whether reversing changes in the support tissue around drainage cells can help lower eye pressure for people with steroid-induced high eye pressure and open-angle glaucoma.
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Molecular networks that keep memory lasting in brain circuits
Researchers are studying how certain molecules keep memories active in brain circuits, with a focus on Alzheimer’s-related memory problems.
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House Ball family support to improve HIV prevention and care for Black sexual and gender minorities
This program brings House Ball family-based retreats and peer-led support to Black and Latinx sexual and gender minority people to help with HIV prevention and staying connected to care.
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How genes and life experiences affect depression in people from diverse backgrounds
This project looks at how genetic differences and environmental experiences relate to major depression in people from many ancestry groups.
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p27 protein test to predict response to CDK4/6 drugs
A lab test that measures a chemical change on the p27 protein to help predict which people with advanced breast cancer will benefit from CDK4/6 drugs like palbociclib, abemaciclib, or ribociclib.
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How common cold, polio, and related viruses start making proteins
Researchers are looking at the viral 'start signal' in rhinovirus, poliovirus and related viruses that lets them hijack cell machinery to make viral proteins, with the aim of helping people affected by those infections.
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How social connections affect mental health, substance use, and HIV care during COVID
This project looks at how loneliness and social connections relate to mental health, substance use, and staying on HIV treatment for people living with HIV during the COVID era.
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How lung type II cells control surfactant and lipid balance
This research is seeing if a protein called LRP1 in surfactant-producing lung cells helps keep surfactant fats balanced to protect breathing in adults.
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Genetics of Alcohol Use, Recovery, and Brain Health
This project looks at genes, brain measures, and life experiences in large families affected by alcohol problems to learn what influences risk, recovery, and relapse, especially for people aged 40 and older.
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Family genetics and brain health in alcohol use
This project looks at how genes, brain function, and life experiences influence alcohol use and recovery in people from families affected by alcohol problems, especially those aged 40 and older.
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Understanding Alcohol Use and Recovery Across Adulthood
This project looks at how genes, brain changes, and life circumstances affect drinking, recovery, and relapse in adults as they age.
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Cell and blood sample bank for families affected by alcohol problems
This project collects and stores blood, cells, and health information from families with alcohol use problems to help researchers learn why some people develop and recover from alcohol use disorder.
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COGA: a long-term family program on alcohol use disorder
This program follows families affected by alcohol use disorder to learn how genes, brain health, and life experiences influence drinking and recovery as people get older.
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Family genetics of alcohol use disorder
This project looks at how genes, brain function, and life circumstances shape alcohol problems, recovery, and relapse in people from large families, with a new focus on those aged 40 and older.
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Improving Mental Health Care with Advanced Tools
This work aims to use advanced data methods to help people with psychiatric conditions get the right diagnosis and treatment faster.
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Understanding the Ethics of HIV Studies for Young People in Africa
This project aims to understand and overcome challenges in including young people at high risk for HIV in health studies in sub-Saharan Africa.
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Psychosis in African and Caribbean communities
This project compares clinical care and whole-genome DNA information to learn why psychosis looks and responds differently in people from African and Caribbean backgrounds and related groups in the US.
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Exploring effective mentorship networks for underrepresented researchers
This study is looking at how to improve support for early career researchers from underrepresented groups by creating better mentorship networks with multiple mentors, so they can succeed in their academic careers.
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Genetic links between PTSD and alcohol problems from adolescence to adulthood
This research looks at how genes and childhood trauma together relate to PTSD and alcohol problems from the teen years into adulthood.
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