Psychosis in people from diverse ancestries
Psychosis in Ancestrally Diverse Settings (PADS)
This project compares how psychotic illnesses start, progress, and respond to treatment in adults of African and Caribbean ancestry in the US, Nigeria, and Trinidad and Tobago.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-11382602 on NIH RePORTER |
What this research studies
If you take part, researchers will collect clinical information from people receiving care for psychosis at hospitals and clinics in Brooklyn, Ibadan, and St. Augustine. Participants will also provide DNA samples so the team can do whole-genome sequencing to look for genetic differences linked to illness and treatment response. The project matches inpatients and outpatients across sites and compares results to large U.S. datasets to see which genetic risk scores work across ancestries. Findings will combine clinical and genomic data to understand similarities and differences in symptoms, outcomes, and treatment effects across these communities.
Who could benefit from this research
Good fit: Adults diagnosed with a psychotic disorder who receive care at participating sites in Brooklyn (SUNY Downstate), Ibadan (Nigeria), or St. Augustine (Trinidad and Tobago) are the ideal candidates.
Not a fit: People without a psychotic disorder, those treated outside the participating locations, or whose ancestry is not represented may not receive direct benefit from this project.
Why it matters
Potential benefit: Results could lead to better genetic risk tools and more tailored treatments for people of African and Caribbean ancestry with psychosis.
How similar studies have performed: Earlier INTREPID pilot work established local case-finding, but applying whole-genome sequencing and cross-population polygenic comparisons in African and Caribbean groups is relatively new.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Bigdeli, Tim Bernard — Suny Downstate Medical Center
- Study coordinator: Bigdeli, Tim Bernard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.