Cross-talk between SARM1-driven axon damage and ferroptosis in brain hemorrhage
Official title: Cross-talk Between Sarmoptosis and Ferroptosis in Hemorrhagic Stroke
Funded at Suny Downstate Medical Center · NIH-11600981 · Data updated 2026-11-12
A study in people with brain bleeding (intracerebral hemorrhage) to understand how axons get damaged and how iron-related cell death contributes to disability.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project start | September 11, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $606,833 |
| NIH project number | 7R01NS140765-02 |
| Project ID | NIH-11600981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with intracerebral hemorrhage or at risk of ICH who could contribute samples or participate in mechanism-focused studies in the context of ongoing preclinical work.
✕Less likely to help
Patients without ICH or without agreement to participate in mechanistic studies may not directly benefit.
What this research studies
This project looks at how nerve fibers in the brain deteriorate after a hemorrhagic stroke and how the iron-related cell death process called ferroptosis might be involved. Researchers will build on lab findings about SARM1, a protein that drives axon degeneration, and test how hemin from blood breakdown might trigger this pathway after bleeding in the brain. The team plans to connect molecular insights to potential targets that could protect axons and improve recovery. The work combines animal or cellular models with human data to better understand mechanisms that could inform future therapies for ICH patients.
Why it matters
Potential benefit: If successful, the research could identify new targets to protect brain connections after hemorrhagic stroke and guide development of therapies to reduce disability.
How similar studies have gone: Previous findings suggest SARM1 and ferroptosis pathways contribute to axon damage, supporting the potential relevance of this approach.
Where this research is happening
-
Suny Downstate Medical Center
Brooklyn, United States Active
Researchers
- Principal investigator: Ratan, Rajiv R — Suny Downstate Medical Center
- Study coordinator: Ratan, Rajiv R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.