Psychosis in Diverse Settings: Understanding Global Differences in Treatment and Genomics
Official title: Psychosis in Ancestrally Diverse Settings (PADS)
Funded at Suny Downstate Medical Center · NIH-11392945 · Data updated 2026-11-12
Aims to understand how psychotic disorders differ in people from diverse global backgrounds and how genetic factors relate to treatment outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project start | August 7, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $230,096 |
| NIH project number | 5R01MH137768-03 |
| Project ID | NIH-11392945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with psychotic disorders across participating sites in the Global South and the US.
✕Less likely to help
Patients not enrolled in the inpatient cohorts or without psychotic disorders may not directly benefit.
What this research studies
This grant brings together researchers from New York, Nigeria, and the Caribbean to study how psychotic disorders present and respond to treatment in global south settings. It will enroll patients receiving inpatient care and use state-of-the-art genome sequencing to explore genetic factors linked to psychosis. The team will compare these populations with US studies to see if current genetic risk scores apply across diverse groups. Findings could highlight new approaches to care that consider ancestry and regional differences. The project builds on prior INTREPID work to deepen understanding of untreated psychosis and treatment responses in varied populations.
Why it matters
Potential benefit: If successful, patients from diverse backgrounds could receive more accurate diagnoses and personalized treatment approaches in the future.
How similar studies have gone: Prior INTREPID studies showed feasibility of cross-population comparisons and laid groundwork for genomic analyses in diverse groups.
Where this research is happening
-
Suny Downstate Medical Center
Brooklyn, United States Active
Researchers
- Principal investigator: Bigdeli, Tim Bernard — Suny Downstate Medical Center
- Study coordinator: Bigdeli, Tim Bernard
Related research
Other NIH-funded projects on the same topics.
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Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
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Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.