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Clinical trials and research at Sanofi
As of November 12, 2026, Find a Trial lists 83 clinical trials run by Sanofi that are recruiting, at sites in 71 countries (most in United States (53), Germany (35), Italy (33)). 1 was first registered in the last 30 days. By phase: Phase 3 (22), Phase 2 (12), Phase 1/2 (9), Phase 1 (7). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 83Clinical trials
- 1New in 30 days
- 71Countries
Newest trials
All recruiting trials (83)
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Tolebrutinib in real-world MS care for patients treated by clinicians
This real-world study sees how tolebrutinib is used for multiple sclerosis patients and what outcomes look like in everyday practice.
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Omicron-based COVID-19 vaccine with Matrix-M given as a single dose in older adults and high-risk individuals
A single-dose Omicron-subvariant vaccine with Matrix-M is tested to see if it is safe and can induce an immune response in adults 65+ and in younger adults with conditions that raise the risk of severe COVID-19, who were previously vaccinated.
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Rilzabrutinib in adults with severe kidney impairment vs. normal kidney function
This study tests how rilzabrutinib behaves in the body and its safety in adults with severe kidney impairment compared to healthy adults.
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Duvakitug in adults with moderate to severe hidradenitis suppurativa
This study tests different doses of duvakitug to see if it helps adults with moderate to severe hidradenitis suppurativa compared with placebo.
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RSV+HMPV protein shot for adults 60 and older
A single shot of a two-virus vaccine is being tested in adults 60+ to see if it can prevent RSV and hMPV infections compared with placebo.
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Egg-based H5N8 influenza vaccine at multiple doses with or without adjuvant in healthy adults
This trial tests whether an egg-based H5N8 flu vaccine, given at low to high doses with or without an adjuvant, is safe and can provoke a stronger immune response in healthy adults 18 and older.
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Belumosudil vs Best Available Therapy for chronic graft-versus-host disease
In people aged 12 and up with chronic graft-versus-host disease, the study tests belumosudil to see if it works better than the doctor’s choice of best available therapy after prior treatments have failed.
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RSV+HMPV vaccine candidate in adults aged 60 and older
A vaccine candidate for RSV and HMPV will be tested in adults 60+ to see if it safely provokes an immune response and how it compares to placebo.
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Is its immune response and safety in babies and toddlers when given a meningococcal vaccine in China
This study tests whether the MenACYW conjugate vaccine safely produces an immune response in healthy infants and toddlers in China, compared with locally licensed vaccines.
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IV sarilumab for adults with rheumatoid arthritis
This study tests IV sarilumab to see how it works and how safe it is for adults with moderately to severely active rheumatoid arthritis, with or without certain standard arthritis medicines.
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Dose-Optimization/Expansion of SAR445877 in adults with advanced gastric or GEJ cancer
This phase 2 study tests SAR445877 as a single-drug treatment to see if it helps adults in China with advanced gastric or GEJ cancer after at least one prior therapy.
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A daily pill test of SAR448851 for early Alzheimer’s disease
This study tests whether taking SAR448851 by mouth once daily can help people with early Alzheimer’s disease compare to a placebo.
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First-in-human study of SAR447971
This study tests SAR447971 against placebo in healthy adults and in people with hidradenitis suppurativa to see how the drug behaves and whether it is safe.
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Post‑marketing safety check of MenQuadfi in children and adults in Korea
This real‑world surveillance in Korea tests MenQuadfi for safety in people from 6 weeks to 55 years old who are receiving it for the first time.
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Dupilumab in COPD: Real-world Registry of Outcomes
This registry tests how dupilumab works for COPD patients in everyday care and whether it lowers flare-ups and improves lung function and quality of life.
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Understanding asthma characteristics and outcomes in routine care
This project will collect information and follow people with asthma to see how symptoms, treatments, biomarkers, and quality of life change over time, especially among those using inhaled corticosteroids.
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Different vaccine formulations for RSV or H5 flu in adults 18–49
This trial will try several vaccine formulations that produce either the RSV antigen or the H5 flu antigen in healthy adults 18 to 49 to see if they are safe and trigger immune responses.
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Dupilumab's effect on anxiety and depression in moderate-to-severe atopic dermatitis
This project will see if dupilumab reduces anxiety and depression in people with moderate-to-severe atopic dermatitis who are starting or recently started the medicine.
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Real-world outcomes for people with Type 1 diabetes treated with teplizumab through managed access programs
This project will look at health records to see how teplizumab is being used and how people's Type 1 diabetes progressed after receiving it through managed access programs.
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Frexalimab versus tacrolimus to prevent kidney transplant rejection
This trial will test whether frexalimab injections given for up to five years work as well and are as safe as tacrolimus capsules at preventing rejection in adults getting their first kidney transplant who have low-to-moderate immune risk.
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Long-term follow-up of dupilumab treatment for COPD
This project will follow adults with uncontrolled COPD and high blood eosinophils who start dupilumab in routine care to see if it is safe and improves symptoms and quality of life over 36 months.
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Long-term outcomes of teplizumab in routine care
This project will see if teplizumab given to people with Stage 2 Type 1 Diabetes delays the start of Stage 3 diabetes and how it affects their quality of life over time.
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Comparing three production lots of a 21‑valent pneumococcal vaccine in infants
This trial will test if three different production lots of a 21‑valent pneumococcal vaccine give similar immune responses and are as safe as the licensed 20‑valent vaccine when given to infants starting at about 2 months of age.
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Comparing under-the-skin versus intravenous frexalimab for adults with multiple sclerosis
This will test whether subcutaneous frexalimab given every 4 weeks works as well as intravenous frexalimab every 4 weeks for adults with relapsing MS or non-relapsing secondary progressive MS.
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Tracking teens and adults with atopic dermatitis who start or change systemic treatment
This registry will follow people aged 12 and up with atopic dermatitis who start or switch systemic treatments to see how well the treatments work and how safe they are in everyday care.
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Sarilumab for early polymyalgia rheumatica in adults
This study tests whether sarilumab given every two weeks, with a prednisone taper, helps people with early polymyalgia rheumatica more than placebo plus prednisone taper.
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Fitusiran prophylaxis for boys aged 1 to under 12 with severe hemophilia A or B
This study tests whether fitusiran given as prophylaxis can reduce bleeding in boys aged 1 to under 12 with severe hemophilia A or B, with or without inhibitors.
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Post-market safety check of Efluelda in older adults after a flu vaccination
This study tests whether Efluelda is safe for adults aged 65 and older when used in routine clinical care after it has been marketed.
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Real-world comparison of experiences for people with stage 2 type 1 diabetes who did or did not receive teplizumab
This study will compare real-world experiences, quality of life, and disease progression for people aged 8 and older with stage 2 type 1 diabetes who received teplizumab versus similar people who did not.
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Single-dose 21-valent pneumococcal conjugate vaccine for children and teens with sickle cell disease
This trial tests whether a single dose of the new PCV21 vaccine is safe and helps children and teens (ages 2–17) with sickle cell disease make protective antibodies compared with the licensed 20-valent pneumococcal vaccine.
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SAR445399 treatment for adults with moderate to severe hidradenitis suppurativa
This will test two doses of SAR445399 versus placebo in adults with moderate to severe hidradenitis suppurativa to see if it reduces abscesses and inflammatory nodules and is safe.
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One-time intravitreal SAR446597 injection for geographic atrophy due to AMD
This trial will try a single eye injection of SAR446597 to slow geographic atrophy in people 60 and older with AMD.
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Real-world safety monitoring of Beyfortus (nirsevimab) in Korean infants and toddlers
This program follows children up to 24 months in Korea who receive Beyfortus to see if the medicine is safe when used in routine care.
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Lunsekimig versus placebo for eosinophilic COPD
This trial tests whether subcutaneous lunsekimig can help adults 40–80 with inadequately controlled COPD who have a high blood eosinophil count.
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Lunsekimig versus placebo for inadequately controlled eosinophilic COPD
This study tests whether regular subcutaneous lunsekimig helps adults aged 40–80 with eosinophilic COPD that remains uncontrolled despite triple inhaled therapy.
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Rilzabrutinib versus placebo for adults with IgG4-related disease (52-week treatment)
This 52-week study will try rilzabrutinib tablets to see if they prevent disease flares and better control symptoms in adults with active IgG4-related disease compared with placebo.
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Duvakitug maintenance treatment for moderate-to-severe ulcerative colitis
This trial tests whether duvakitug can help keep adults with moderately to severely active ulcerative colitis in clinical response after a successful induction treatment.
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Duvakitug to induce remission in moderate to severe ulcerative colitis
This 12-week treatment will test whether duvakitug helps adults (and some older teens) with moderately to severely active ulcerative colitis get into remission and feel better.
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Duvakitug maintenance treatment for moderately to severely active Crohn's disease.
We will test whether duvakitug can keep symptoms controlled in adults with moderately to severely active Crohn's disease who responded to initial treatment.
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Induction treatment with duvakitug for moderate to severe Crohn's disease
This trial will test whether duvakitug helps adults with moderate to severe Crohn's disease improve symptoms over a 12-week induction period compared with placebo.
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Brivekimig for moderate to severe hidradenitis suppurativa
This trial will test whether brivekimig can reduce symptoms in people with moderate to severe hidradenitis suppurativa.
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SAR444336 to help adults with microscopic colitis stay in remission while on budesonide.
This will test whether adding SAR444336 to budesonide helps adults with microscopic colitis who are in remission stay symptom-free longer than placebo.
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Belumosudil treatment for children with chronic graft-versus-host disease (schoolROCK)
This trial will test whether the oral drug belumosudil helps children ages 1 to under 18 with moderate-to-severe chronic graft-versus-host disease that has not improved after at least two prior systemic treatments.
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Teplizumab versus placebo for recent-onset Stage 3 Type 1 diabetes in people aged 1–25
This will test whether an IV course of teplizumab can improve blood sugar control and reduce the need for mealtime insulin over one year in people aged 1–25 who were recently diagnosed with stage 3 type 1 diabetes.
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Oral rilzabrutinib versus placebo for adults with warm autoimmune hemolytic anemia
This trial tests whether the oral drug rilzabrutinib can raise and sustain hemoglobin better than placebo in adults with primary warm autoimmune hemolytic anemia who have not had lasting benefit from steroids.
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Dupilumab injections to reduce airway inflammation in adults 40–85 with COPD
This trial will test whether dupilumab injections can reduce airway inflammation and mucus plugging and improve breathing, exacerbations, and quality of life in people aged 40–85 with moderate-to-severe COPD and evidence of type 2 inflammation.
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Dupilumab for adults with COPD and high blood eosinophils in routine care
This study will try dupilumab in adults with uncontrolled COPD and high blood eosinophils to see if it improves symptoms, quality of life, and safety over 24 months in routine care.
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Early detection of Type 1 diabetes in children and adolescents who have a parent or sibling with Type 1 diabetes
This project will test a screening process to find pre-symptomatic Type 1 diabetes in kids and teens who have a first-degree relative with Type 1 diabetes.
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Acne mRNA vaccine for adults with mild facial acne
This trial will test two injections of an acne mRNA vaccine versus placebo in adults 18–45 with mild facial acne to see if it's safe, triggers an immune response, and improves acne.
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Oral rilzabrutinib for adults with immune thrombocytopenia after first-line treatment fails.
This study will test whether the oral drug rilzabrutinib can raise and keep platelet counts up in adults with ITP who did not have lasting benefit from first-line therapy.
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Rilzabrutinib treatment for adults with Graves' disease
This trial will test two doses of the oral drug rilzabrutinib in adults with Graves' disease, with or without Graves' orbitopathy, to see which dose better controls hyperthyroidism and is safe.
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Evaluating Rilzabrutinib for Sickle Cell Disease in Patients Aged 10 to 65
This study is testing a new medication called rilzabrutinib to see if it can help people aged 10 to 65 with sickle cell disease have fewer pain crises and improve their overall health.
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Treatment outcomes for people with chronic inflammatory demyelinating polyneuropathy (CIDP)
See if current CIDP treatments are helping people who still have nerve weakness or disability after at least three months on standard therapy.
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SAR442970 treatment for moderate-to-severe Crohn's disease.
This trial will test whether two different doses of SAR442970 work better than placebo for people with moderate-to-severe Crohn's disease who have not had an adequate response or cannot tolerate standard or advanced therapies.
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Weekly efanesoctocog alfa for hemophilia A with joint synovial hypertrophy
This trial tests whether taking efanesoctocog alfa once a week for 12 months can reduce synovial hypertrophy in people aged 12 and older with moderate to severe hemophilia A.
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Chlamydia mRNA vaccine for young adults
This study is testing a new Chlamydia mRNA vaccine in young adults aged 18 to 29 to see if it is safe and effective.
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SAR446268 gene therapy for non-congenital myotonic dystrophy type 1
This will try a single intravenous dose of SAR446268 gene therapy to lower toxic DMPK mRNA and improve muscle function in people aged 10 to 55 with non‑congenital myotonic dystrophy type 1.
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Long-term assessment of dupilumab for eosinophilic esophagitis in Germany
This study is testing how well dupilumab works and how safe it is for people aged 12 and older with eosinophilic esophagitis in Germany over two years.
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Evaluating iGlarLixi for managing Type 2 Diabetes in Chinese patients
This study is testing whether a new diabetes treatment called iGlarLixi can help Chinese patients with Type 2 Diabetes better control their blood sugar compared to a standard medication.
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Avalglucosidase alfa treatment for children with Pompe disease
This study is testing a new treatment called avalglucosidase alfa to see if it helps children with infantile-onset Pompe disease feel better over a year.
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Evaluating DR-0201 for autoimmune diseases
This study is testing a new drug called DR-0201 to see if it can help people with autoimmune diseases like lupus and Sjogren's syndrome feel better and how safe it is.
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Investigating SAR446523 for treating relapsed/refractory myeloma
This study is testing a new treatment called SAR446523 for adults with relapsed or refractory multiple myeloma to see how well it works and find the best dose to use.
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Evaluating treatments for kidney diseases in young to middle-aged adults
This study is testing three different treatments for kidney diseases in young to middle-aged adults to see if they can reduce protein levels in urine and help with symptoms over 24 weeks.
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Registry for patients with Stage 2 Type 1 Diabetes
This study is looking to see how well the treatment TZIELD can help people with Stage 2 Type 1 Diabetes by tracking their health over time compared to those who aren't using the treatment.
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Evaluating DR-0201 for patients with relapsed B-cell Non-Hodgkin Lymphoma
This study is testing a new treatment called DR-0201 to see if it can help adults with relapsed B-cell non-Hodgkin lymphoma who have already tried other therapies.
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Evaluating an mRNA vaccine for treating moderate to severe acne
This study is testing a new mRNA vaccine to see if it can safely help adults aged 18 to 45 with moderate to severe acne.
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Investigating Dupilumab for Children with Prurigo Nodularis
This study is testing if Dupilumab can help children with prurigo nodularis feel better and stay safe while using the medication.
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Testing riliprubart for treating chronic inflammatory demyelinating polyneuropathy
This study is testing if a new treatment called riliprubart can work better than the usual IVIg treatment for adults with chronic inflammatory demyelinating polyneuropathy (CIDP).
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Long-term safety and immune response of olipudase alfa in young children with acid sphingomyelinase deficiency
This study is testing the long-term safety and immune response of a treatment called olipudase alfa in young children under 2 years old who have acid sphingomyelinase deficiency.
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Observing how adolescents with severe atopic dermatitis respond to dupilumab treatment
This study looks at how well dupilumab treatment works for teenagers aged 12 to 17 with severe eczema over a year, focusing on their symptoms and quality of life.
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Testing fitusiran to prevent bleeds in severe hemophilia A patients switching from emicizumab
This study is testing if fitusiran can help prevent bleeding in men with severe hemophilia A who are switching from another treatment called emicizumab.
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Testing the effectiveness of belumosudil for treating lung transplant rejection
This study is testing if belumosudil can help improve lung function in adults who have had a lung transplant and are experiencing ongoing issues with their new lungs.
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Safety study of avalglucosidase alfa during pregnancy
This study is looking at how safe the drug avalglucosidase alfa is for pregnant women and their babies during pregnancy and breastfeeding.
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Testing SAR445877 for advanced solid tumors
This study is testing a new cancer treatment called SAR445877 to see if it can help adults with advanced solid tumors feel better and improve their health, both on its own and with other cancer therapies.
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Treatment of chronic itching with dupilumab
This study is testing if a medication called dupilumab can help adults with severe chronic itching feel better.
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Monitoring outcomes of women and their babies after MenQuadfi® vaccination during pregnancy
This study is looking at the health of pregnant women and their babies after they receive the MenQuadfi® vaccine to see if there are any effects from the vaccination.
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Combining Isatuximab with New Treatments for Refractory Plasma Cell Myeloma
This study is testing a new combination of isatuximab with other treatments to see if it helps people with tough-to-treat plasma cell myeloma feel better.
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Registry for pregnant women vaccinated with Dengvaxia
This study is tracking the health of pregnant women and their babies who received the Dengvaxia vaccine to see how it affects their pregnancies and infant development.
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Finding the right dose of sarilumab for children with systemic juvenile idiopathic arthritis
This study is testing the right dose of sarilumab to see how well it works and how safe it is for children and teens with systemic juvenile idiopathic arthritis.
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Tracking pregnancy outcomes in women with Pompe disease
This study looks at the pregnancy experiences and outcomes for women with Pompe disease to see how it affects both them and their babies.
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Registry tracking outcomes for patients with Gaucher disease
This study tracks the health and progress of people with Gaucher disease to help improve treatment and care for them, including those who are pregnant.
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Global registry for tracking Pompe disease outcomes
This study is tracking the health and progress of people with Pompe disease to learn more about how it affects them and to see how well treatments are working.
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Registry for tracking Fabry disease and pregnancy outcomes
This study is tracking the health of pregnant women with Fabry disease to see how pregnancy affects them and their babies.
Quick answers
How many clinical trials run by Sanofi are recruiting right now?
83, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 71 countries. The most sites are in United States (53 trials), Germany (35 trials), Italy (33 trials), Canada (31 trials), Spain (31 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 22, Phase 2: 12, Phase 1/2: 9, Phase 1: 7. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.