Role of inflammatory signals in stress erythropoiesis
Official title: Role of IL-1 beta signaling in stress erythropoiesis
Funded at Pennsylvania State University, the · NIH-11427772 · Data updated 2026-11-12
This project looks at how inflammation changes the way the body makes red blood cells during stress and anemia, to understand why steady production drops and stress pathways kick in.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $641,869 |
| NIH project number | 1R01DK148738-01 |
| Project ID | NIH-11427772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with anemia or inflammatory diseases where stress erythropoiesis may be activated.
✕Less likely to help
Healthy individuals without anemia or inflammation may not directly benefit from this research.
What this research studies
In people, red blood cells are normally produced to replace those that are lost. When infection or inflammation occurs, signals like TNF-α and IL-1β shift production toward immune cells, which can reduce normal erythropoiesis. The study explores how stress erythropoiesis activates alternative pathways and whether human sites outside the bone marrow contribute to red blood cell formation during anemia. Researchers will compare human samples and mouse data to map the stress erythropoiesis niche and the cells involved. The goal is to uncover targets that could help maintain or restore red blood cell production during inflammatory states.
Why it matters
Potential benefit: If successful, the findings could point to new ways to treat anemia by supporting red blood cell production during inflammation.
How similar studies have gone: Previous work in mice supports similar stress erythropoiesis pathways, with human data suggesting conservation, but specifics in humans need clearer translation.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Paulson, Robert Frank — Pennsylvania State University, the
- Study coordinator: Paulson, Robert Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.